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Showing 1–24 of 24 results
Advanced filters: Author: April Cook Clear advanced filters

  • Petrels are wide-ranging, highly threatened seabirds that often ingest plastic. This study used tracking data for 7,137 petrels of 77 species to map global exposure risk and compare regions, species, and populations. The results show higher exposure risk for threatened species and stress the need for international cooperation to tackle marine litter.

    • Bethany L. Clark
    • Ana P. B. Carneiro
    • Maria P. Dias
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • An estimated AU$583 billion per year cost of in situ recovery of terrestrial and freshwater species in Australia, including through habitat restoration and retention and management of invasive species, is not an expected conservation budget, but exemplifies the severe cost of nature declines.

    • April E. Reside
    • Josie Carwardine
    • James E. M. Watson
    Research
    Nature Ecology & Evolution
    Volume: 9, P: 425-435

  • Nucleosome positioning and chromatin accessibility are important contributors to the regulation of gene expression. Here the authors describe a method that allows the simultaneous measurement of nucleosome occupancy and chromatin accessibility in the same assay, revealing new features of chromatin organization linked to gene regulation.

    • Jakub Mieczkowski
    • April Cook
    • Michael Y. Tolstorukov
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • Changes in chromatin structure impact gene expression programs by modulating accessibility to the transcription machinery. Here, West et al. explore differences in nucleosome occupancy between mammalian pluripotent and somatic cells and uncover regulatory regions likely to play key roles in determining cell identity.

    • Jason A. West
    • April Cook
    • Robert E. Kingston
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12

  • Species are largely predicted to shift polewards as global temperatures increase. Now research—based on historical changes in the distribution of Australian birds—shows that if only poleward shifts in distribution are considered, the fingerprint of climate change is underestimated by an average of 26% in temperate regions and 95% in tropical regions.

    • Jeremy VanDerWal
    • Helen T. Murphy
    • April E. Reside
    Research
    Nature Climate Change
    Volume: 3, P: 239-243

  • An analysis of human chromosome 15 — which is altered in Prader-Willi and Angelman syndromes — reveals that it resembles a hall of mirrors, as it contains a number of sequence duplications throughout its length. The evolutionary events that may have led to the high number of duplications was also reconstructed.

    • Michael C. Zody
    • Manuel Garber
    • Chad Nusbaum
    Research
    Nature
    Volume: 440, P: 671-675

  • Sentinel lymph-node biopsy is an accurate staging procedure for patients with melanoma. However, this procedure followed by immediate completion lymph-node dissection (CLND) does not seem to improve survival, based on data from the MSLT-1 randomized trial. Patients with micrometastases <0.1 mm have a similar clinical course to sentinel-node-negative patients and routine CLND may not be indicated in these patients. The authors discuss the issue of prognostic false positivity and explain how the Rotterdam Criteria could be useful for the measurement of sentinel node tumor burden.

    • Alexander C. J. van Akkooi
    • Cornelis Verhoef
    • Alexander M. M. Eggermont
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 7, P: 446-454

  • The genome of the grey short-tailed opossum Monodelphis domestica has been sequenced and analyzed, giving a first peek at a marsupial's genetic code. Of particular interest are the genetics of the immune system, which has been studied as a model for humans, and of the X chromosome for historical reasons.

    • Tarjei S. Mikkelsen
    • Matthew J. Wakefield
    • Kerstin Lindblad-Toh
    Research
    Nature
    Volume: 447, P: 167-177

  • An assessment of the habitat of native vertebrate species burnt by the 2019–2020 Australian mega-fires shows that 70 taxa were severely affected.

    • Michelle Ward
    • Ayesha I. T. Tulloch
    • James E. M. Watson
    Research
    Nature Ecology & Evolution
    Volume: 4, P: 1321-1326

  • After previously discovering that the ion channel TRPA1 is used as an internal temperature sensor in Drosophila to control the slow response of flies to shallow thermal gradients, the authors show here that the rapid response of flies to steep warming gradients relies on a different protein, GR28B, providing the first example of a thermosensory role for a gustatory receptor.

    • Lina Ni
    • Peter Bronk
    • Paul A. Garrity
    Research
    Nature
    Volume: 500, P: 580-584

  • A friend in need.

    • Keith Brooke
    Comments & Opinion
    Nature
    Volume: 467, P: 494

  • Lack of information on authors’ contribution to specific aspects of a study hampers reproducibility and replicability. Here, the authors propose a new, easily implemented reporting system to clarify contributor roles in the Methods section of an article.

    • Shinichi Nakagawa
    • Edward R. Ivimey-Cook
    • Malgorzata Lagisz
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 14, P: 1-5

  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186

  • Brain metastases remain a serious obstacle in the successful treatment of patients with solid tumors. This Review discusses what is known about the biology of brain metastases, what preclinical models are available to study the disease, and which novel therapeutic strategies are being studied in patients.

    • April F. Eichler
    • Euiheon Chung
    • Rakesh K. Jain
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 8, P: 344-356