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Showing 1–3 of 3 results
Advanced filters: Author: Aram Comjean Clear advanced filters

  • The fruit fly Drosophila melanogaster has emerged as a model to characterize the mechanisms of tumor-induced host organ dysfunction. Here, Xu, Liu et al. describe a mechanism of tumor-induced kidney dysfunction through hyper-activation of the PvR/JNK/Jra pathway in the Principal cells of the fly kidney/Malpighian tubules.

    • Jun Xu
    • Ying Liu
    • Norbert Perrimon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • A subpopulation of cholinergic neurons triggers Ca2+ currents among enterocytes to promote return to homeostasis after injury, and disruption of this process leads to gut inflammation and hyperplasia in Drosophila.

    • Afroditi Petsakou
    • Yifang Liu
    • Norbert Perrimon
    Research
    Nature
    Volume: 623, P: 122-131