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Showing 1–4 of 4 results
Advanced filters: Author: Aran Singanayagam Clear advanced filters

  • Obesity is a risk factor for severe influenza infection. Here, Almond et al show that increased susceptibility is due to increased airway concentrations of the hormone leptin which dampens interferon responses and facilitates severe infection.

    • Mark Almond
    • Hugo A. Farne
    • Aran Singanayagam
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Virus infection is known to be a trigger for exacerbations in chronic obstructive respiratory disease (COPD). Here the authors investigate how formation of neutrophil extracellular traps (NETs) contribute to the exacerbation of COPD through release of dsDNA using animal models and samples from human participants.

    • Orestis Katsoulis
    • Marie Toussaint
    • Aran Singanayagam
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • Human airway epithelium infected with SARS-CoV-2 shows viral entry occurring at the apical plasma membrane, excluding cilia. Here, the visualization of viral fusion at the cell surface and budding profiles within infected cells through high-resolution electron microscopy and tomography provide new insight into the infection process.

    • Andreia L. Pinto
    • Ranjit K. Rai
    • Thomas Burgoyne
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ.

    • Aran Singanayagam
    • Nicholas Glanville
    • Sebastian L. Johnston
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16