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Nature Genetics (1)

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Advanced filters: Author: Aravind Nambiar Kalathil Clear advanced filters

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

High levels of fumarate or succinate suppress the homologous-recombination DNA-repair pathway in cancer cells that are deficient for FH or SDH, respectively. These tumor cells are vulnerable to PARP inhibitors.

Parker L. Sulkowski
Ranjini K. Sundaram
Peter M. Glazer
Research16 Jul 2018
Nature Genetics

Volume: 50, P: 1086-1092

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