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Showing 1–13 of 13 results
Advanced filters: Author: Aravinthan D.T. Samuel Clear advanced filters

  • SmartEM is a ‘smart’ pipeline for electron microscopy-based data acquisition for connectomics. In order to efficiently image large datasets, the approach involves imaging at short pixel dwell times and identifying problematic regions that are then imaged with longer dwell times and therefore higher quality.

    • Yaron Meirovitch
    • Ishaan Singh Chandok
    • Nir Shavit
    Research
    Nature Methods
    Volume: 23, P: 193-204

  • An optogenetic illumination system based on the use of a digital micromirror device and video tracking software is reported, which allows real-time light delivery with high spatial resolution to specified targets in freely moving Caenorhabditis elegans. Also in this issue, Stirman et al. report a similar illumination system using a liquid crystal display projector. Both methods allow optogenetic perturbation of a variety of neural circuits in the behaving worm.

    • Andrew M Leifer
    • Christopher Fang-Yen
    • Aravinthan D T Samuel
    Research
    Nature Methods
    Volume: 8, P: 147-152

  • Serial-section electron microscopy is used to reconstruct the full brain connectome of eight individual Caenorhabditis elegans at various stages of development, providing insight into the principles underlying brain maturation.

    • Daniel Witvliet
    • Ben Mulcahy
    • Mei Zhen
    Research
    Nature
    Volume: 596, P: 257-261

  • While gustatory systems have been extensively studied in adult Drosophila, not much is known about taste coding at the larval stage. Here, the authors investigate gustatory receptor neurons in larvae and find single neurons are capable of responding to more than one taste modality.

    • Lena van Giesen
    • Luis Hernandez-Nunez
    • Simon G. Sprecher
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • A device for generating precise spatial and temporal patterns of airborne odorants is reported. In combination with machine vision tracking software, the authors use the device to monitor navigation of freely moving Drosophila melanogaster larvae.

    • Marc Gershow
    • Matthew Berck
    • Aravinthan D T Samuel
    Research
    Nature Methods
    Volume: 9, P: 290-296

  • The development of systems combining rapid volumetric imaging with three-dimensional tracking has enabled the measurement of brain-wide dynamics in freely behaving animals such as worms, flies, and fish. These advances provide an exciting opportunity to understand the organization of neural circuits in the context of voluntary and natural behaviors. In this Comment, we highlight recent progress in this burgeoning area of research.

    • John A. Calarco
    • Aravinthan D. T. Samuel
    Comments & Opinion
    Nature Methods
    Volume: 16, P: 14-15

  • New approaches to integrate high-dimensional recordings of brain activity with single-neuron resolution with simultaneous recordings of natural animal behaviour enable the study of brain-wide activity in small animals including worms, flies and fish during behaviours and decision-making. This Review surveys experimental and theoretical approaches that have opened this area of systems neuroscience.

    • Albert Lin
    • Daniel Witvliet
    • Vivek Venkatachalam
    Reviews
    Nature Reviews Physics
    Volume: 4, P: 292-305