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Advanced filters: Author: Ari J. Johannesson Clear advanced filters

Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease

Here, the authors conduct a GWAS for autoimmune thyroid disease, finding 225 loci including a start codon variant in LAG3 that confers a 3.4-fold risk of autoimmune thyroid disease and reduces expression and plasma levels of LAG−3.

Saedis Saevarsdottir
Kristbjörg Bjarnadottir
Kari Stefansson
ResearchOpen Access09 Jul 2024
Nature Communications

Volume: 15, P: 1-12
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease

A predicted loss-of-function germline mutation in FLT3 causes a reduction in full-length FLT3, with a compensatory increase in the levels of FLT3 ligand, leading to increased risk of autoimmune thyroid disease.

Saedis Saevarsdottir
Thorunn A. Olafsdottir
Kari Stefansson
Research24 Jun 2020
Nature

Volume: 584, P: 619-623
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

Sigurgeir Olafsson
Pernilla Stridh
Kari Stefansson
ResearchOpen Access08 Aug 2017
npj Genomic Medicine

Volume: 2, P: 1-12