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Showing 1–2 of 2 results
Advanced filters: Author: Ariana Sulpizio Clear advanced filters

  • Potential ligand class-dependent differences in STING activation have both evolutionary and therapeutic implications. Here, the authors observe a unique oligomerization state of STING with an open-LBD ligand, suggesting additional regulatory mechanisms involved in activation by this ligand class.

    • Anant Gharpure
    • Ariana Sulpizio
    • Andrew B. Ward
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Activation of STING-dependent signal transduction results in adaptive immune responses that promote antitumor immunity. A recent study has identified a small-molecule STING agonist that functions by binding to a newly discovered ligandable site to induce high-order STING oligomerization.

    • Ariana Sulpizio
    • Luke L. Lairson
    News & Views
    Nature Chemical Biology
    Volume: 20, P: 266-267