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Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K⁺ channel

The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, and prevents atrial fibrillation.

Marieke W. Veldkamp
Guillaume S. C. Geuzebroek
Ruben Coronel
ResearchOpen Access19 Oct 2018
Nature Communications

Volume: 9, P: 1-15
Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Connie R Bezzina
Julien Barc
Richard Redon
Amendments and Corrections29 Oct 2013
Nature Genetics

Volume: 45, P: 1409
Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation

Functional human atrial myocytes derived from foetal atrial tissue can be massively expanded via a conditional cell-immortalization method, and used in in vitro models of atrial fibrillation.

Niels Harlaar
Sven O. Dekker
Antoine A. F. de Vries
Research06 Jan 2022
Nature Biomedical Engineering

Volume: 6, P: 389-402
Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Julien Barc
Rafik Tadros
Connie R. Bezzina
Amendments and Corrections26 Apr 2022
Nature Genetics

Volume: 54, P: 735
Knock-in swine model reveals new arrhythmia mechanism in Timothy syndrome

Timothy syndrome is a severe variant of long QT syndrome, but an accurate in vivo model to study the disease and identify treatments has been lacking. A knock-in swine model of Timothy syndrome now shows that CaMKII-mediated reduction in peak I_Na slows the cardiac impulse propagation and contributes to the severe arrhythmia in the disorder.

Bastiaan J. Boukens
Arie O. Verkerk
Connie R. Bezzina
News & Views20 Dec 2023
Nature Cardiovascular Research

Volume: 3, P: 18-20
Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells

The development of human cardiovascular progenitor cells provides a renewable source of cardiac cell types.

Matthew J Birket
Marcelo C Ribeiro
Christine L Mummery
Research01 Sept 2015
Nature Biotechnology

Volume: 33, P: 970-979
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Genome-wide association analyses identify new susceptibility loci for Brugada syndrome. Functional studies implicate microtubule-related trafficking effects on sodium channel expression as an underlying molecular mechanism.

Julien Barc
Rafik Tadros
Connie R. Bezzina
Research24 Feb 2022
Nature Genetics

Volume: 54, P: 232-239
hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

Christiaan C. Veerman
Isabella Mengarelli
Connie R. Bezzina
ResearchOpen Access03 Aug 2016
Scientific Reports

Volume: 6, P: 1-10
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Connie Bezzina, Richard Redon and colleagues show that common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disorder with high risk of sudden cardiac death. The newly discovered loci have a large cumulative effect on disease risk and illustrate how common variants can have a strong impact on predisposition to rare diseases.

Connie R Bezzina
Julien Barc
Richard Redon
Research21 Jul 2013
Nature Genetics

Volume: 45, P: 1044-1049
Identification of an I_Na-dependent and I_to-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Dongrui Ma
Zhenfeng Liu
Heming Wei
ResearchOpen Access26 Jul 2018
Scientific Reports

Volume: 8, P: 1-11
Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling

Lejla Medzikovic
Cees A. Schumacher
Vivian de Waard
ResearchOpen Access21 Oct 2015
Scientific Reports

Volume: 5, P: 1-15
Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model

Gerard A. Marchal
Maaike van Putten
Carol Ann Remme
ResearchOpen Access07 May 2021
Scientific Reports

Volume: 11, P: 1-11

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