Nature Search

Experimental strategies for the genetic dissection of complex traits in animal models

Ariel Darvasi
Reviews01 Jan 1998
Nature Genetics

Volume: 18, P: 19-24
Localization of genes controlling resistance to trypanosomiasis in mice

Stephen J. Kemp
Fuad Iraqi
Alan J. Teale
Research01 Jun 1997
Nature Genetics

Volume: 16, P: 194-196
Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael O'Donovan and colleagues present a genome-wide association study of schizophrenia in 479 cases and 2,937 controls, followed by replication in several cohorts. They report evidence for association for a susceptibility allele near ZNF804A.

Michael C O'Donovan
Nicholas Craddock
Michael J Owen
Research30 Jul 2008
Nature Genetics

Volume: 40, P: 1053-1055
Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder

Schizophrenia and bipolar disorder are important psychiatric disorders with overlapping genetic components. Here, the authors identify and replicate a genome-wide significant risk locus for the two disorders, and suggest a role for NDST3in severe psychiatric disease.

Todd Lencz
Saurav Guha
Ariel Darvasi
ResearchOpen Access19 Nov 2013
Nature Communications

Volume: 4, P: 1-10
The value of isolated populations

Sagiv Shifman
Ariel Darvasi
Correspondence01 Aug 2001
Nature Genetics

Volume: 28, P: 309-310
Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins

Ashkenazi Jews are a genetically isolated population with distinct patterns of genetic diversity. Here, the authors sequence the genomes of 128 Ashkenazi Jewish individuals and use the sequence information to provide insight into the population's European and Middle Eastern origins.

Shai Carmi
Ken Y. Hui
Itsik Pe’er
ResearchOpen Access09 Sept 2014
Nature Communications

Volume: 5, P: 1-9
Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Stratified medicine promises to tailor treatment for individual patients, however it remains a major challenge to leverage genetic risk data to aid patient stratification. Here the authors introduce an approach to stratify individuals based on the aggregated impact of their genetic risk factor profiles on tissue-specific gene expression levels, and highlight its ability to identify biologically meaningful and clinically actionable patient subgroups, supporting the notion of different patient ‘biotypes’ characterized by partially distinct disease mechanisms.

Lucia Trastulla
Georgii Dolgalev
Michael J. Ziller
ResearchOpen Access01 Jul 2024
Nature Communications

Volume: 15, P: 1-28
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.

Christian R Marshall
Daniel P Howrigan
Jonathan Sebat
Research21 Nov 2016
Nature Genetics

Volume: 49, P: 27-35
Gene expression meets genetics

Genetic analyses look for differences in gene sequence that could explain variation in physical traits. Gene-expression studies provide a snapshot of active genes. These approaches are now combined, to great effect.

Ariel Darvasi
News & Views20 Mar 2003
Nature

Volume: 422, P: 269-270
The beauty of admixture

Admixture mapping is an old concept that has only now been applied with markers across the entire genome. Such a study scanning an African American population identified two chromosomal regions affecting susceptibility to hypertension.

Ariel Darvasi
Sagiv Shifman
News & Views01 Feb 2005
Nature Genetics

Volume: 37, P: 118-119
Closing in on complex traits

A new study involving a population of 1,904 heterogeneous mice bred for 50 generations, phenotyped for 101 traits and genotyped for 13,459 SNPs, presents the most comprehensive analysis thus far of complex traits in mice. The work represents a landmark resource for the mouse genetics community and offers important insights into the genetic architecture of complex traits.

Ariel Darvasi
News & Views01 Aug 2006
Nature Genetics

Volume: 38, P: 861-862
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

This study uses gene expression predictors for the dorsolateral prefrontal cortex and other brain regions to perform a transcriptomic imputation analysis of schizophrenia, identifying 413 genic associations across 13 brain regions and 36 significantly enriched pathways.

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Research25 Mar 2019
Nature Genetics

Volume: 51, P: 659-674
Complement genes contribute sex-biased vulnerability in diverse disorders

Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

Nolan Kamitaki
Aswin Sekar
Steven A. McCarroll
Research11 May 2020
Nature

Volume: 582, P: 577-581
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Russell L. McLaughlin
Dick Schijven
Michael C. O’Donovan
ResearchOpen Access21 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Biological insights from 108 schizophrenia-associated genetic loci

Schizophrenia is a highly heritable genetic disorder, however, identification of specific genetic risk variants has proven difficult because of its complex polygenic nature—a large multi-stage genome-wide association study identifies 128 independent associations in over 100 loci (83 of which are new); key findings include identification of genes involved in glutamergic neurotransmission and support for a link between the immune system and schizophrenia.

Stephan Ripke
Benjamin M. Neale
Michael C. O’Donovan
Research22 Jul 2014
Nature

Volume: 511, P: 421-427
Deletion and Insertion Mutations in Short Tandem Repeats in the Coding Regions of Human Genes

Ariel Darvasi
Batsheva Kerem
Research01 Jan 1995
European Journal of Human Genetics

Volume: 3, P: 14-20
Difference in Frequencies of the Cystic Fibrosis Alleles, ΔF508 and W1282X, between Carriers and Patients

Yoram M. Kalman
Eitan Kerem
Batsheva Kerem
Research01 Apr 1994
European Journal of Human Genetics

Volume: 2, P: 77-82
Expanded genetic screening panel for the Ashkenazi Jewish population

Brett Baskovich
Susan Hiraki
Carole Oddoux
Research03 Sept 2015
Genetics in Medicine

Volume: 18, P: 522-528
A polygenic resilience score moderates the genetic risk for schizophrenia

Jonathan L. Hess
Daniel S. Tylee
Stephen J. Glatt
ResearchOpen Access06 Sept 2019
Molecular Psychiatry

Volume: 26, P: 800-815
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Laura M. Huckins
Amanda Dobbyn
Eli A. Stahl
Amendments and Corrections13 May 2019
Nature Genetics

Volume: 51, P: 1068
The Collaborative Cross, a community resource for the genetic analysis of complex traits

The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

Gary A Churchill
David C Airey
Fei Zou
Comments & Opinion01 Nov 2004
Nature Genetics

Volume: 36, P: 1133-1137
Age at first birth in women is genetically associated with increased risk of schizophrenia

Guiyan Ni
Jacob Gratten
Michael C. O’Donovan
ResearchOpen Access05 Jul 2018
Scientific Reports

Volume: 8, P: 1-14

Search

Experimental strategies for the genetic dissection of complex traits in animal models

Localization of genes controlling resistance to trypanosomiasis in mice

Identification of loci associated with schizophrenia by genome-wide association and follow-up

Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder

The value of isolated populations

Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Gene expression meets genetics

The beauty of admixture

Closing in on complex traits

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Complement genes contribute sex-biased vulnerability in diverse disorders

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Biological insights from 108 schizophrenia-associated genetic loci

Deletion and Insertion Mutations in Short Tandem Repeats in the Coding Regions of Human Genes

Difference in Frequencies of the Cystic Fibrosis Alleles, ΔF508 and W1282X, between Carriers and Patients

Expanded genetic screening panel for the Ashkenazi Jewish population

A polygenic resilience score moderates the genetic risk for schizophrenia

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

The Collaborative Cross, a community resource for the genetic analysis of complex traits

Age at first birth in women is genetically associated with increased risk of schizophrenia

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