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Showing 1–8 of 8 results
Advanced filters: Author: Arif Yurdagul Clear advanced filters

  • Efferocytosis describes the engulfment and clearance of apoptotic cells by phagocytes. Here the authors identify in primary mouse macrophage WDFY3 as a regulator for efferocytosis, in which c-terminal WDFY3 is sufficient to modulate degradation while full-length WDFY3 is required to modulate the uptake of apoptotic cells.

    • Jianting Shi
    • Xun Wu
    • Hanrui Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • Ampomah et al. show that apoptotic cell-derived methionine taken up by macrophages during efferocytosis plays a role in mediating tissue resolution by providing a substrate for DNA methylation and repression of the ERK1/2 phosphatase Dusp4, causing activation of ERK1/2 and expression of pro-resolving mediators

    • Patrick B. Ampomah
    • Bishuang Cai
    • Ira Tabas
    Research
    Nature Metabolism
    Volume: 4, P: 444-457

  • Clearing away dead cells — a process known as efferocytosis — is crucial for normal tissue homeostasis and is impaired in several pathological processes. This Review describes new insights into how efferocytes deal with the engulfed dead cell cargo, how efferocytosis supports the resolution of inflammation and how this understanding is informing new therapeutic strategies.

    • Amanda C. Doran
    • Arif Yurdagul Jr
    • Ira Tabas
    Reviews
    Nature Reviews Immunology
    Volume: 20, P: 254-267

  • Atherosclerosis is characterized by low-grade, chronic inflammation, and the balance between pro-inflammatory and inflammation-resolving mechanisms dictates the clinical outcomes. This Review discusses the specific causes of inflammation and the mechanisms underlying the impaired resolution of inflammation that characterize clinically dangerous atherosclerotic lesions and highlights the potential of pro-resolving mediator therapy for the prevention and treatment of atherosclerotic cardiovascular disease.

    • Magnus Bäck
    • Arif Yurdagul Jr
    • Petri T. Kovanen
    Reviews
    Nature Reviews Cardiology
    Volume: 16, P: 389-406