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Advanced filters: Author: Arijit A. Adhikari Clear advanced filters

A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria

Characterization of a biosynthetic pathway for the sulfonation of steroidal metabolites, such as cholesterol, by gut bacteria may have implications for immune cell trafficking and inflammatory bowel disease.

Lina Yao
Gabriel D. D’Agostino
A. Sloan Devlin
Research18 Aug 2022
Nature Microbiology

Volume: 7, P: 1404-1418
Development of a covalent inhibitor of gut bacterial bile salt hydrolases

A covalent pan-inhibitor of bacterial bile salt hydrolases developed by adding a chenodeoxycholic acid moiety to the warhead is not bactericidal and is therefore useful for studying the effects of bile acids on host physiology.

Arijit A. Adhikari
Tom C. M. Seegar
A. Sloan Devlin
Research10 Feb 2020
Nature Chemical Biology

Volume: 16, P: 318-326

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A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria

Development of a covalent inhibitor of gut bacterial bile salt hydrolases

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