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Showing 1–3 of 3 results
Advanced filters: Author: Arimantas Lionikas Clear advanced filters

  • Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis. Here, the authors analyze 1,063 LG x SM AIL mice to identify significant associations for 50 traits relevant to human health and disease.

    • Natalia M. Gonzales
    • Jungkyun Seo
    • Abraham A. Palmer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Abraham Palmer and colleagues use genotyping by sequencing to perform genome-wide association studies on CFW mice for behavioral, physiological and gene expression traits. They find many QTLs and incorporate expression QTL analysis to prioritize specific genes at loci of interest that underlie different complex traits.

    • Clarissa C Parker
    • Shyam Gopalakrishnan
    • Abraham A Palmer
    Research
    Nature Genetics
    Volume: 48, P: 919-926

  • Jonathan Flint, Richard Mott and colleagues employ low-coverage (0.15×) sequencing and their new imputation method STITCH to perform genome-wide association analysis for complex traits in an outbred mouse population. They find >250 QTLs for 92 phenotypes and obtain gene-level mapping resolution for around 20% of the loci.

    • Jérôme Nicod
    • Robert W Davies
    • Jonathan Flint
    Research
    Nature Genetics
    Volume: 48, P: 912-918