Although reported to improvein vitrofertilization outcomes, androgen supplementation of women with low functional ovarian reserve (LFOR) has remained controversial. In this Review, Aya Shohat-Tal and colleagues discuss genetic variants and polymorphisms associated with inefficient metabolism of dehydroepiandrosterone (DHEA) to testosterone and how, following DHEA supplementation, the hormonal profiles of hypoandrogenic women reflect their ability to metabolize DHEA to testosterone.
- Aya Shohat-Tal
- Aritro Sen
- Norbert Gleicher
