The Hermansky-Pudlak Syndrome 4 protein (HPS4) mediates trafficking between late endosomes and lysosomes and is now shown to inhibit small RNA-mediated silencing (RNAi) in flies and human cells. Components of the ESCRT complex, which mediates late endosome trafficking, are required for efficient miRNA-mediated silencing and additional results support the idea that RNAi effectors are functionally linked to endosome-associated compartments.
- Young Sik Lee
- Sigal Pressman
- Richard W. Carthew
