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Communications Biology (2)
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Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases

Arnaud Chignon et al. present an integrated analysis of single-cell expression data from blood and genome-wide studies to identify expressed genes (eGenes) associated with human lifespan. The 125 eGenes identified are enriched for cardiometabolic traits and disorders and 16 are causally related to lifespan, as shown by Mendelian Randomization analysis.

Arnaud Chignon
Valentin Bon-Baret
Patrick Mathieu
ResearchOpen Access01 May 2020
Communications Biology

Volume: 3, P: 1-15
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity

Mickael Rosa
Arnaud Chignon
Patrick Mathieu
ResearchOpen Access20 Sept 2019
npj Genomic Medicine

Volume: 4, P: 1-10
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank

Kim Valette et al. perform a genomic study on asthma integrating genome-wide association study, functional mapping using lung and blood transcriptome-wide profiles, as well as Mendelian randomization. They show candidate causal genes expressed in lung and blood tissues that are putative therapeutic targets for asthma.

Kim Valette
Zhonglin Li
Yohan Bossé
ResearchOpen Access08 Jun 2021
Communications Biology

Volume: 4, P: 1-15

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