Nature Search

Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

The EWSR1::FLI1 fusion protein is the oncogenic driver of Ewing sarcoma (EwS). Here, the authors find that EWSR1::FLI1 plays a non-canonical role in mRNA decay via interactions with the CCR4-NOT deadenylation complex and the RNA-binding protein HuR. This role uncovers a new therapeutic vulnerability of EwS to HuR inhibition.

Bartimée Galvan
Loïc Ongena
Franck Dequiedt
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-24
P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

Wood and colleagues report that the XPO1 inhibitor selinexor activates PI3Ky-dependent AKT signaling in AML via upregulation of P2RY2 and demonstrate a synergistic effect of combining selinexor with inhibition of prosurvival AKT signaling.

Kevin H. Lin
Justine C. Rutter
Kris C. Wood
Research06 Jun 2022
Nature Cancer

Volume: 3, P: 837-851
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Androgen receptor (AR) signalling regulates cellular metabolism in prostate cancer. Here, the authors perform a proteomics and metabolomics characterisation of prostate cancer cells adapted to long-term resistance to AR inhibition and show rewiring of glucose and lipid metabolism, and further identify a signature associated with resistance to AR inhibition.

Arnaud Blomme
Catriona A. Ford
Hing Y. Leung
ResearchOpen Access19 May 2020
Nature Communications

Volume: 11, P: 1-17
Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes

Spinal muscular atrophy (SMA) is an autosomal recessive disorder with no present cure. Here the authors perform an in vitro screening leading to the identification of a small molecule that alters the conformational dynamics of the TSL2 RNA structure and acts as a modulator of SMN exon 7 splicing.

Amparo Garcia-Lopez
Francesca Tessaro
Leonardo Scapozza
ResearchOpen Access23 May 2018
Nature Communications

Volume: 9, P: 1-12
A convergent mixed methods to study registration on kidney transplantation waiting list refusal by women and men on dialysis in France

Latame Komla ADOLI
Arnaud CAMPEON
Sahar BAYAT-MAKOEI
ResearchOpen Access24 Nov 2024
Scientific Reports

Volume: 14, P: 1-13
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Chromodomain Helicase DNA-binding (CHD) proteins have been implicated in neurodevelopmental processes. Here, the authors identify missense variants in CHD3 that disturb its chromatin remodeling activities and cause a neurodevelopmental disorder with macrocephaly and speech and language impairment.

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
ResearchOpen Access05 Nov 2018
Nature Communications

Volume: 9, P: 1-12
Multiple metrics assessment method for a reliable evaluation of corneal suturing skills

Lea Dormegny
Nicole Neumann
Tristan Bourcier
ResearchOpen Access20 Feb 2023
Scientific Reports

Volume: 13, P: 1-9
Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers

Aleksandra Georgievski
Pierre-Simon Bellaye
Ronan Quéré
ResearchOpen Access11 May 2024
Cell Death & Disease

Volume: 15, P: 1-17
Author Correction: Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome

Pierre Vabres
Arthur Sorlin
Jean-Baptiste Rivière
Amendments and Corrections14 Oct 2019
Nature Genetics

Volume: 51, P: 1660
Author Correction: Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome

Pierre Vabres
Arthur Sorlin
Jean-Baptiste Rivière
Amendments and Corrections07 Feb 2020
Nature Genetics

Volume: 52, P: 353
Sexual display complexity varies non-linearly with age and predicts breeding status in greater flamingos

Charlotte Perrot
Arnaud Béchet
Frank Cézilly
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-10
4D Thermomechanical metamaterials for soft microrobotics

4D metamaterials offer the additional functionality of being responsive to external stimuli. Here, a metamaterial-based soft robot is composed of bilayer plates that can rotate and translate in response to thermal stimuli, allowing controlled motion.

Qingxiang Ji
Johnny Moughames
Muamer Kadic
ResearchOpen Access09 Sept 2021
Communications Materials

Volume: 2, P: 1-6
Cost and efficacy of peripheral stem cell mobilization strategies in multiple myeloma

Zoé Van de Wyngaert
Virginie Nerich
Xavier Leleu
Research23 May 2020
Bone Marrow Transplantation

Volume: 55, P: 2254-2260
A single nucleotide polymorphism of IL6-receptor is associated with response to tocilizumab in rheumatoid arthritis patients

Cécile Luxembourger
Adeline Ruyssen-Witrand
Yves-Marie Pers
Research16 Jan 2019
The Pharmacogenomics Journal

Volume: 19, P: 368-374
Optical analogue of the dynamical Casimir effect in a dispersion-oscillating fibre

Observing the dynamical Casimir effect, where two particles are generated from the vacuum, is challenging in the optical regime due to its purely-temporal nature. The authors demonstrate a dispersion-oscillating fibre system operating in the near-infrared regime and capable of resolving correlated photon pairs as an analogue to the dynamical Casimir effect.

Stefano Vezzoli
Arnaud Mussot
Daniele Faccio
ResearchOpen Access19 Jul 2019
Communications Physics

Volume: 2, P: 1-6
Intestinal release of biofilm-like microcolonies encased in calcium-pectinate beads increases probiotic properties of Lacticaseibacillus paracasei

Arnaud Heumann
Ali Assifaoui
Aurélie Rieu
ResearchOpen Access28 Oct 2020
npj Biofilms and Microbiomes

Volume: 6, P: 1-12
An implicit and reliable neural measure quantifying impaired visual coding of facial expression: evidence from the 22q11.2 deletion syndrome

Arnaud Leleu
Emilie Favre
Caroline Demily
ResearchOpen Access04 Feb 2019
Translational Psychiatry

Volume: 9, P: 1-11
Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome

Postzygotic inactivating mutations in RHOA cause a mosaic neuroectodermal syndrome characterized by linear hypopigmentation, leukoencephalopathy and craniofacial anomalies, highlighting the role of RHOA in human development and disease.

Pierre Vabres
Arthur Sorlin
Jean-Baptiste Rivière
Research30 Sept 2019
Nature Genetics

Volume: 51, P: 1438-1441
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access15 Feb 2019
Nature Communications

Volume: 10, P: 1-4
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language

Lot Snijders Blok
Justine Rousseau
Philippe M. Campeau
Amendments and CorrectionsOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-4
Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disability, a rare recessive neuroectodermal syndrome

Thomas Besnard
Natacha Sloboda
Bertrand Isidor
Research06 Feb 2019
Genetics in Medicine

Volume: 21, P: 2025-2035
Author Correction: Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids

Philippe Besnard
Jeffrey E. Christensen
Rémy Burcelin
Amendments and CorrectionsOpen Access22 Jun 2018
Scientific Reports

Volume: 8, P: 1
BRAT1–related disorders: phenotypic spectrum and phenotype-genotype correlations from 97 patients

Camille Engel
Stéphanie Valence
Juliette Piard
Research21 Jun 2023
European Journal of Human Genetics

Volume: 31, P: 1023-1031
Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death

Claire Delehouzé
Arnaud Comte
Stéphane Bach
ResearchOpen Access24 Mar 2022
Scientific Reports

Volume: 12, P: 1-10
Idiosyncratic invasion trajectories of human bacterial pathogens facing temperature disturbances in soil microbial communities

Ascensio-Schultz Eliette
Barbier Elodie
Piveteau Pascal
ResearchOpen Access29 May 2024
Scientific Reports

Volume: 14, P: 1-13
Major discrepancy between factual antibiotic resistance and consumption in South of France: analysis of 539,037 bacterial strains

Ousmane Oumou Diallo
Sophie Alexandra Baron
Jean-Marc Rolain
ResearchOpen Access26 Oct 2020
Scientific Reports

Volume: 10, P: 1-9
Continental-scale patterns of hyper-cryptic diversity within the freshwater model taxon Gammarus fossarum (Crustacea, Amphipoda)

Remi Wattier
Tomasz Mamos
Michał Grabowski
ResearchOpen Access06 Oct 2020
Scientific Reports

Volume: 10, P: 1-16
A European-wide dataset to uncover adaptive traits of Listeria monocytogenes to diverse ecological niches

Benjamin Félix
Yann Sevellec
Sophie Roussel
ResearchOpen Access28 Apr 2022
Scientific Data

Volume: 9, P: 1-12
Obese Subjects With Specific Gustatory Papillae Microbiota and Salivary Cues Display an Impairment to Sense Lipids

Philippe Besnard
Jeffrey E. Christensen
Rémy Burcelin
ResearchOpen Access30 Apr 2018
Scientific Reports

Volume: 8, P: 1-15
Domestication-driven changes in plant traits associated with changes in the assembly of the rhizosphere microbiota in tetraploid wheat

Aymé Spor
Agathe Roucou
Cyrille Violle
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Tubular filamentation for laser material processing

Chen Xie
Vytautas Jukna
Francois Courvoisier
ResearchOpen Access10 Mar 2015
Scientific Reports

Volume: 5, P: 1-8
Rogue waves and analogies in optics and oceanography

An analogy between wave propagation in hydrodynamics and in optics has yielded new insights into the mechanisms leading to the formation of giant rogue waves on the ocean. We review experimental progress and field measurements in this area.

John M. Dudley
Goëry Genty
Frédéric Dias
Reviews23 Sept 2019
Nature Reviews Physics

Volume: 1, P: 675-689
Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

Clara Grilo
Tomé Neves
Eric Guinard
ResearchOpen Access31 Mar 2025
Scientific Data

Volume: 12, P: 1-14
iPSCs derived from infertile men carrying complex genetic abnormalities can generate primordial germ-like cells

Aurélie Mouka
Brahim Arkoun
Lucie Tosca
ResearchOpen Access22 Aug 2022
Scientific Reports

Volume: 12, P: 1-14
Maternal outcomes and risk factors for COVID-19 severity among pregnant women

Manon Vouga
Guillaume Favre
Alice Panchaud
ResearchOpen Access06 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Identifying early indicators of secondary peritonitis in critically ill patients with cirrhosis

Carole Ruault
Nathalie Zappella
Stephane Legriel
ResearchOpen Access26 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Unraveling negative biotic interactions determining soil microbial community assembly and functioning

Sana Romdhane
Aymé Spor
Laurent Philippot
ResearchOpen Access28 Jul 2021
The ISME Journal

Volume: 16, P: 296-306
Exceptional fossil assemblages confirm the existence of complex Early Triassic ecosystems during the early Spathian

Christopher P. A. Smith
Thomas Laville
Arnaud Brayard
ResearchOpen Access04 Oct 2021
Scientific Reports

Volume: 11, P: 1-12
The landscape of epilepsy-related GATOR1 variants

Sara Baldassari
Fabienne Picard
Stéphanie Baulac
ResearchOpen Access10 Aug 2018
Genetics in Medicine

Volume: 21, P: 398-408
Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia

N Jourdan-Da Silva
Y Perel
J Clavel
ResearchOpen Access06 Jan 2004
British Journal of Cancer

Volume: 90, P: 139-145
High rate of hypomorphic variants as the cause of inherited ataxia and related diseases: study of a cohort of 366 families

Mehdi Benkirane
Cecilia Marelli
Michel Koenig
Research07 Jul 2021
Genetics in Medicine

Volume: 23, P: 2160-2170
Correction to: The landscape of epilepsy-related GATOR1 variants

Sara Baldassari
Fabienne Picard
Stéphanie Baulac
Amendments and Corrections29 Aug 2018
Genetics in Medicine

Volume: 21, P: 1671
Correction: The landscape of epilepsy-related GATOR1 variants

Sara Baldassari
Fabienne Picard
Stéphanie Baulac
Amendments and Corrections27 Sept 2018
Genetics in Medicine

Volume: 21, P: 1896

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