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Showing 1–5 of 5 results

Advanced filters: Author: Arno Alpi Clear advanced filters

The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway

Georgina Mosedale
Wojciech Niedzwiedz
Ketan J Patel
Research21 Aug 2005
Nature Structural & Molecular Biology

Volume: 12, P: 763-771
ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis

Arno F Alpi
Aude Echalier
News & ViewsOpen Access24 Aug 2017
Cell Death & Disease

Volume: 8, P: e3021
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

Structures and biochemistry reveal how covalent linkage of a ubiquitin-like protein elicits protein–protein interactions indirectly. NEDD8 allosterically activates CUL5-RBX2 cullin-RING E3 binding to the ARIH2 RBR-type E3 for joint ubiquitylation.

Sebastian Kostrhon
J. Rajan Prabu
Brenda A. Schulman
ResearchOpen Access13 Sept 2021
Nature Chemical Biology

Volume: 17, P: 1075-1083
Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

High-throughput screening and structure-guided design identified small-molecule inhibitors that prevent the interaction between N-terminally acetylated E2 conjugating enzyme UBE2M and DCN1, an E3 ligase for the ubiquitin-like protein Nedd8.

Daniel C Scott
Jared T Hammill
R Kip Guy
Research05 Jun 2017
Nature Chemical Biology

Volume: 13, P: 850-857
Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage

Jean-François Maure
Sandra C. Moser
Ronald T. Hay
ResearchOpen Access17 May 2016
Scientific Reports

Volume: 6, P: 1-10