Podocytes, a key component of the glomerular filtration barrier, adhere tightly to the glomerular basement membrane (GBM) through the actions of extracellular ligands within the GBM, transmembrane podocyte adhesion receptors, and intracellular linker proteins. This Review summarizes recent advances in our understanding of the cell biology and genetics of podocyte adhesion with a focus on its functional relevance in physiology and disease.
- Norman Sachs
- Arnoud Sonnenberg
