Nature Search

The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders

This genetic study utilizing the newest available GWAS summary statistics provides evidence on the relationship between cannabis use, cannabis use disorder and a range of psychiatric disorders.

Marco Galimberti
Cassie Overstreet
Joel Gelernter
ResearchOpen Access29 May 2025
Nature Mental Health

Volume: 3, P: 700-708
Stress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions

The authors evaluated and integrated compositional and functional microbiota data using fecal samples taken from healthy individuals and multimodal neuroimaging.

Eric An
Desiree R. Delgadillo
Arpana Gupta
Research21 Jun 2024
Nature Mental Health

Volume: 2, P: 935-950
Discrimination exposure impacts unhealthy processing of food cues: crosstalk between the brain and gut

Gupta and colleagues use multi-omic analyses of neuroimaging and fecal metabolites to identify brain–gut–microbiome disruptions in response to discrimination that may affect preference for unhealthy eating patterns and predispose individuals experiencing discrimination-related stress to obesity.

Xiaobei Zhang
Hao Wang
Arpana Gupta
ResearchOpen Access02 Oct 2023
Nature Mental Health

Volume: 1, P: 841-852
Early life adversity impacts alterations in brain structure and food addiction in individuals with high BMI

Soumya Ravichandran
Riya Sood
Arpana Gupta
ResearchOpen Access07 Jun 2024
Scientific Reports

Volume: 14, P: 1-13
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

Multi-ancestry genome-wide association meta-analyses identify risk loci for cannabis use disorder. Genomic structural equation modeling and genetic correlation analyses show overlap with several other traits, including impulsivity and psychopathology.

Daniel F. Levey
Marco Galimberti
Joel Gelernter
ResearchOpen Access20 Nov 2023
Nature Genetics

Volume: 55, P: 2094-2103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures

Michelle Guan
Tien S. Dong
Arpana Gupta
ResearchOpen Access26 Jun 2023
Scientific Reports

Volume: 13, P: 1-21
Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index

Kilpatrick et al. investigate the relationship between neighborhood disadvantage, trans-fatty acid intake, body mass index, stress and cortical microstructure. Results suggest obesogenic aspects of neighborhood disadvantage could disrupt information processing flexibility in regions involved in reward, emotion regulation and cognition.

Lisa A. Kilpatrick
Keying Zhang
Arpana Gupta
ResearchOpen Access15 Sept 2023
Communications Medicine

Volume: 3, P: 1-8
Brain–gut–microbiome interactions in obesity and food addiction

Food addiction is an eating behaviour that reflects alterations in brain–gut–microbiome (BGM) interactions and a shift towards hedonic mechanisms. This Review summarizes the physiology of food addiction in obesity as it relates to BGM interactions and provides insights into treatment targets for food addiction aimed at each level of the BGM axis.

Arpana Gupta
Vadim Osadchiy
Emeran A. Mayer
Reviews27 Aug 2020
Nature Reviews Gastroenterology & Hepatology

Volume: 17, P: 655-672
Machine learning model to predict obesity using gut metabolite and brain microstructure data

Vadim Osadchiy
Roshan Bal
Arpana Gupta
ResearchOpen Access04 Apr 2023
Scientific Reports

Volume: 13, P: 1-13
Functional brain rewiring and altered cortical stability in ulcerative colitis

Hao Wang
Jennifer S. Labus
Emeran A. Mayer
ResearchOpen Access19 Jan 2022
Molecular Psychiatry

Volume: 27, P: 1792-1804
Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals

Soumya Ravichandran
Ravi R. Bhatt
Arpana Gupta
ResearchOpen Access09 Feb 2021
Scientific Reports

Volume: 11, P: 1-15
Analysis of brain networks and fecal metabolites reveals brain–gut alterations in premenopausal females with irritable bowel syndrome

Vadim Osadchiy
Emeran A. Mayer
Arpana Gupta
ResearchOpen Access02 Nov 2020
Translational Psychiatry

Volume: 10, P: 1-8
A neuropsychosocial signature predicts longitudinal symptom changes in women with irritable bowel syndrome

Ravi R. Bhatt
Arpana Gupta
Emeran A. Mayer
ResearchOpen Access24 Nov 2021
Molecular Psychiatry

Volume: 27, P: 1774-1791
Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Manav Kapoor
Jen-Chyong Wang
Alison Goate
ResearchOpen Access14 Feb 2019
Translational Psychiatry

Volume: 9, P: 1-11
Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease

Nuanyi Liang
Kwangsik Nho
Frank Sacks
ResearchOpen Access29 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Chronic pain in children: structural and resting-state functional brain imaging within a developmental perspective

Ravi R. Bhatt
Arpana Gupta
Lonnie K. Zeltzer
Reviews02 Dec 2019
Pediatric Research

Volume: 88, P: 840-849

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