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  • Inhibitors of the mTOR kinase are in clinical trials for the treatment of cancer; here, mutations in mTOR that can lead to drug resistance are investigated and the results are used to design a new class of mTOR inhibitors that can overcome this resistance.

    • Vanessa S. Rodrik-Outmezguine
    • Masanori Okaniwa
    • Kevan M. Shokat
    Research
    Nature
    Volume: 534, P: 272-276