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Showing 1–12 of 12 results
Advanced filters: Author: Arti Tandon Clear advanced filters

  • Deep whole-genome sequencing of 300 individuals from 142 diverse populations provides insights into key population genetic parameters, shows that all modern human ancestry outside of Africa including in Australasians is consistent with descending from a single founding population, and suggests a higher rate of accumulation of mutations in non-Africans compared to Africans since divergence.

    • Swapan Mallick
    • Heng Li
    • David Reich
    Research
    Nature
    Volume: 538, P: 201-206

  • A complete genome sequence is presented of a female Neanderthal from Siberia, providing information about interbreeding between close relatives and uncovering gene flow events among Neanderthals, Denisovans and early modern humans, as well as establishing substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans.

    • Kay Prüfer
    • Fernando Racimo
    • Svante Pääbo
    Research
    Nature
    Volume: 505, P: 43-49

  • Linda Kao and colleagues use admixture mapping to identify risk variants in MYH9 associated with nondiabetic end-stage renal disease in African Americans. The risk variants are more common in populations with West African ancestry and contribute to the excess burden of end-stage kidney diseases in these populations. A similar finding is reported in an accompanying paper by Cheryl Winkler and colleagues.

    • W H Linda Kao
    • Michael J Klag
    • Rulan S Parekh
    Research
    Nature Genetics
    Volume: 40, P: 1185-1192

  • Christopher Haiman, Bogdan Pasaniuc, David Reich and colleagues report a major role for low-frequency variation in the risk for prostate cancer. They show that alleles with >1% minor allele frequency contribute an order of magnitude more to risk for prostate cancer than these alleles do to overall genetic variation.

    • Nicholas Mancuso
    • Nadin Rohland
    • David Reich
    Research
    Nature Genetics
    Volume: 48, P: 30-35

  • A survey of genetic variation in Native American and Siberian populations reveals that Native Americans are descended from at least three streams of gene flow from Asia: after the initial peopling of the continent there was a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America.

    • David Reich
    • Nick Patterson
    • Andrés Ruiz-Linares
    Research
    Nature
    Volume: 488, P: 370-374

  • Kumarasamy Thangaraj, David Reich and colleagues identify 81 South Asian groups descended from extreme founder events, including 14 with a census size of over 1 million people, thus providing an opportunity to test for and decrease the burden of recessive genetic diseases in these populations.

    • Nathan Nakatsuka
    • Priya Moorjani
    • Kumarasamy Thangaraj
    Research
    Nature Genetics
    Volume: 49, P: 1403-1407

  • Noah Zaitlen, Alkes Price and colleagues report a new approach to estimate the narrow-sense heritability of complex traits from unrelated individuals in a recently admixed population. They apply this approach to estimate the heritability for 13 quantitative or case-control phenotypes in 21,497 African-American individuals and suggest the inflation of family-based h2 estimates.

    • Noah Zaitlen
    • Bogdan Pasaniuc
    • Alkes L Price
    Research
    Nature Genetics
    Volume: 46, P: 1356-1362