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Showing 1–15 of 15 results
Advanced filters: Author: Arturo Zychlinsky Clear advanced filters

  • Arturo Zychlinsky and Volker Brinkman recall the discovery of neutrophil extracellular traps.

    • Volker Brinkmann
    • Arturo Zychlinsky
    Research Highlights
    Nature Reviews Immunology
    Volume: 21, P: 615

  • In addition to their phagocytic activity, neutrophils can also kill microorganisms by the release of neutrophil extracellular traps or NETs — fibrous extracellular structures that are composed of chromatin with proteins from the neutrophilic granules attached. Brinkmann and Zychlinsky provide an overview of the structure, function and generation of NETs.

    • Volker Brinkmann
    • Arturo Zychlinsky
    Reviews
    Nature Reviews Microbiology
    Volume: 5, P: 577-582

  • The enzyme superoxide dismutase 1 (SOD1) protects cells from superoxide toxicity. Zychlinsky and colleagues find that post-translational glutathionylation of caspase-1 by SOD1 triggers caspase-1 activation and subsequent interleukin 1β production.

    • Felix Meissner
    • Kaaweh Molawi
    • Arturo Zychlinsky
    Research
    Nature Immunology
    Volume: 9, P: 866-872

  • Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

    • Garth Lawrence Burn
    • Tobias Raisch
    • Arturo Zychlinsky
    ResearchOpen Access
    Nature
    Volume: 647, P: 747-756

  • Injection of activated protein C (APC) is the last resort to rescue a patient with severe sepsis. Research into how APC works reveals that the drug inactivates histones (pages 1318–1321), which are toxic during severe sepsis.

    • Catherine Chaput
    • Arturo Zychlinsky
    News & Views
    Nature Medicine
    Volume: 15, P: 1245-1246

    • Arturo Zychlinsky
    Research Highlights
    Nature
    Volume: 450, P: 461

  • Platelets act as intermediaries in the pathogenesis of sepsis—sensing bacteria and signaling neutrophils to release fibrous traps that remove bacteria from the bloodstream. This response may also contribute to tissue injury (pages 463–469).

    • Constantin Urban
    • Arturo Zychlinsky
    News & Views
    Nature Medicine
    Volume: 13, P: 403-404

  • Type three secretion systems consist of a multisubunit protein complex that crosses the bacterial membranes and an extracellular needle-shaped structure. New data show that the needle protomer partially refolds from alpha-helix into beta-strand conformation to extend the needle from the distal end. The closely related flagellar system also grows at the tip, but it is not known whether protomer refolding is required for its assembly.

    • Ömer Poyraz
    • Holger Schmidt
    • Michael Kolbe
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 788-792

  • A growing body of evidence indicates that neutrophils and neutrophil extracellular traps (NETs) are involved in the progression of rheumatic diseases. This Review focuses on the role of NETs in systemic lupus erythematosus, vasculitis, rheumatoid arthritis and gout.

    • Falko Apel
    • Arturo Zychlinsky
    • Elaine F. Kenny
    Reviews
    Nature Reviews Rheumatology
    Volume: 14, P: 467-475

  • Neutrophil extracellular traps (NETs) protect against infection, but they are also implicated in the pathology associated with various immune-mediated conditions. This Review describes when and how they are formed, how they function and how they are regulated.

    • Venizelos Papayannopoulos
    Reviews
    Nature Reviews Immunology
    Volume: 18, P: 134-147