Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–3 of 3 results
Advanced filters: Author: Arun Kumar Mahato Clear advanced filters

  • Obesity is a global health challenge with an ongoing need for new medical treatments. Here, the authors show that artesunate, an FDA-approved treatment for severe malaria, can be repurposed for the treatment of obesity via GDF15/GFRAL signaling axis without overt side effects in mice and non-human primates.

    • Xuanming Guo
    • Pallavi Asthana
    • Hoi Leong Xavier Wong
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • The GDF15–GFRAL axis is key for regulating energy homeostasis and body weight. Membrane-bound matrix metalloproteinase 14 is shown to negatively regulate GFRAL, whereas its downregulation protects against diet-induced obesity through increased GDF15 signaling.

    • Chi Fung Willis Chow
    • Xuanming Guo
    • Hoi Leong Xavier Wong
    Research
    Nature Metabolism
    Volume: 4, P: 203-212

  • This paper reports the genome sequence of domesticated tomato, a major crop plant, and a draft sequence for its closest wild relative; comparative genomics reveal very little divergence between the two genomes but some important differences with the potato genome, another important food crop in the genus Solanum.

    • Shusei Sato
    • Satoshi Tabata
    • René M. Klein Lankhorst
    ResearchOpen Access
    Nature
    Volume: 485, P: 635-641