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Showing 1–10 of 10 results
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  • Nuclear receptors (NR) are drug-responsive master regulators. Here, authors map DNA binding profiles of all human NRs. Their MinSeq Find algorithm identifies masked NR binding sites in genomes and maps ~10% of orphan SNPs linked to numerous diseases.

    • Devesh Bhimsaria
    • José A. Rodríguez-Martínez
    • Aseem Z. Ansari
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98–HOXA9, are linked to its ability to self-associate and function through aberrantly phase-separated “onco-condensates.”

    • Tanja Mittag
    • Aseem Z. Ansari
    News & Views
    Nature Structural & Molecular Biology
    Volume: 28, P: 543-545

  • A tenet of drug discovery states that molecules greater than a certain size don't enter cells. But not only do certain synthetic peptides refute this idea, they also inhibit 'undruggable' biological targets.

    • Paramjit S. Arora
    • Aseem Z. Ansari
    News & Views
    Nature
    Volume: 462, P: 171-173

  • Small molecules and drugs are not homogenously distributed across cells, and are instead enriched in distinct subcellular compartments and membraneless biomolecular condensates. A new study lays out the path to identifying chemical features or ‘rationales’ that confer condensate-selective partitioning of small molecules.

    • Aseem Z. Ansari
    News & Views
    Nature Chemical Biology
    Volume: 20, P: 264-265

  • Ten new RNA polymerase II kinases were identified, of these Hrr25 was engineered to enable covalent and noncovalent chemical inhibition in vivo, revealing that this kinase regulates polymerase function at noncoding snoRNA genes.

    • Corey M. Nemec
    • Amit K. Singh
    • Aseem Z. Ansari
    Research
    Nature Chemical Biology
    Volume: 15, P: 123-131

  • Two new approaches promise to facilitate the identification of zinc fingers that function optimally in vivo.

    • Aseem Z. Ansari
    News & Views
    Nature Biotechnology
    Volume: 21, P: 242-243

  • RNA polymerase II is post-translationally modified on its C terminal domain and these modifications have been associated with different states of Pol II transcription. These modifications are now examined at a genome-wide level, and chemical inhibitors are used to argue that promoter-distal Ser7P is specifically placed anew by the Bur1 kinase.

    • Joshua R Tietjen
    • David W Zhang
    • Aseem Z Ansari
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1154-1161

  • As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical intervention extends from the mechanistic dissection of biochemical processes in living cells to the targeted control of gene networks and cell fate.

    • Aseem Z Ansari
    Comments & Opinion
    Nature Chemical Biology
    Volume: 3, P: 2-7