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RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma

Translocation renal cell carcinoma (tRCC) is driven by MiT family gene fusions. Here, the authors demonstrate that RNA-binding features of TFE3 fusions facilitate condensate formation, promoting transcriptional hub assembly and oncogenic gene activation.

Lei Guo
Rongjie Zhao
Yun Huang
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-22

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RNA-mediated condensation of TFE3 oncofusions facilitates transcriptional hub formation to promote translocation renal cell carcinoma

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