In cancer, neoantigen (NeoAg)-specific CD8+ T cells capable of direct tumor recognition have been extensively studied but little is known of the role of NeoAg-specific CD4+ T cells. Here Schoenberger and colleagues analyze an oligoclonal CD4+ T cell response to a naturally arising murine tumor NeoAg at the level of TCR usage and functionality.
- Spencer E. Brightman
- Angelica Becker
- Stephen P. Schoenberger
