ssDNA gaps have emerged as structures which may mediate cytotoxicity of chemotherapeutic agents such as cisplatin. Here, the authors show that the mono-ADPribosyltransferase PARP10 promotes the repair of ssDNA gaps by recruiting RAD18 to initiate PCNA ubiquitination-mediated translesion synthesis.
- Jude B. Khatib
- Ashna Dhoonmoon
- Claudia M. Nicolae
