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Advanced filters: Author: Ashreena Salpekar Clear advanced filters

  • The p110α isoform of phosphoinositide 3-kinase has a critical role in angiogenesis. In particular, it is needed to mediate the migration of endothelial cells downstream of VEGF receptor activation, acting upstream of RhoA. The results suggest that pharmacological inhibition of the p110α isoform may be useful in anti-angiogenesis therapy of cancer.

    • Mariona Graupera
    • Julie Guillermet-Guibert
    • Bart Vanhaesebroeck
    Research
    Nature
    Volume: 453, P: 662-666