Nature Search

Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8⁺ T-cells

HIV remission has been seen in people living with HIV after the cessation of antiretroviral therapy and is termed post treatment control. Here Passaes and colleagues present an SIV model that shows early initiation of antiretroviral therapy after SIV infection is linked to improved post treatment control upon cessation of antiviral therapy and associates with the expansion of an enhanced memory pool of CD8 + T cells‘.

Caroline Passaes
Delphine Desjardins
Asier Sáez-Cirión
ResearchOpen Access11 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells

HIV remission was achieved for 32 months after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells.

Asier Sáez-Cirión
Anne-Claire Mamez
Alexandra Calmy
ResearchOpen Access02 Sept 2024
Nature Medicine

Volume: 30, P: 3544-3554
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

The recipient of an allogeneic stem cell transplant from a CCR5Δ32/Δ32 donor shows evidence of HIV type 1 cure, including the absence of a viral rebound over 4 years after stopping antiretroviral treatment.

Björn-Erik Ole Jensen
Elena Knops
Guido Kobbe
ResearchOpen Access20 Feb 2023
Nature Medicine

Volume: 29, P: 583-587
Metabolic plasticity of HIV-specific CD8⁺ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

Spontaneous control of HIV is linked to the ability of CD8⁺ T cells to eliminate infected CD4⁺ T cells. Here, the authors uncover metabolic differences between HIV-specific, central memory CD8⁺ T cells from spontaneous HIV controllers and antiretrovirally treated non-controllers, and show that in vitro metabolic reprogramming enhances the antiviral response in non-controllers cells.

Mathieu Angin
Stevenn Volant
Asier Sáez-Cirión
Research12 Jul 2019
Nature Metabolism

Volume: 1, P: 704-716
Author Correction: High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells

Erick De La Torre Tarazona
Caroline Passaes
José Alcamí
Amendments and CorrectionsOpen Access17 Jul 2024
Scientific Reports

Volume: 14, P: 1
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

A rare sub-population of people living with HIV-1 experience long-lasting viral remission after interrupting antiretroviral therapy and are considered post-treatment controllers. Here the authors characterise the humoral immune response to HIV-1 in a cohort of post-treatment controllers.

Luis M. Molinos-Albert
Valérie Lorin
Laetitia Laine
ResearchOpen Access11 Apr 2022
Nature Communications

Volume: 13, P: 1-17
Immunometabolism and HIV-1 pathogenesis: food for thought

Immunometabolism has a key role in HIV-1 pathogenesis, with the metabolic state of T cells and macrophages determining their susceptibility to infection, the metabolism of immune cells shaping their response to infection and metabolic products driving inflammation during infection.

Asier Sáez-Cirión
Irini Sereti
Reviews06 Aug 2020
Nature Reviews Immunology

Volume: 21, P: 5-19
Ex vivo T cell–based HIV suppression assay to evaluate HIV-specific CD8⁺ T-cell responses

Asier Sáez-Cirión
So Youn Shin
Gianfranco Pancino
Protocols13 May 2010
Nature Protocols

Volume: 5, P: 1033-1041
High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells

Erick De La Torre Tarazona
Caroline Passaes
José Alcamí
ResearchOpen Access17 Jun 2024
Scientific Reports

Volume: 14, P: 1-9

Search

Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8⁺ T-cells

Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells

In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

Metabolic plasticity of HIV-specific CD8⁺ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

Author Correction: High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

Immunometabolism and HIV-1 pathogenesis: food for thought

Ex vivo T cell–based HIV suppression assay to evaluate HIV-specific CD8⁺ T-cell responses

High concentrations of Maraviroc do not alter immunological and metabolic parameters of CD4 T cells

Search

Quick links

Search

Filter By:

Search

Quick links