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Showing 1–5 of 5 results
Advanced filters: Author: Assaf Amitai Clear advanced filters

  • Standard first line therapy in patients with non-small cell lung cancer is immunotherapy but responses vary and consistent predictive biomarkers are lacking. Here, using RNA-sequencing data from a large clinical trial in NSCLC patients, the authors define four molecular subsets with distinct tumour-intrinsic and -extrinsic features with differing outcomes to immunotherapy combinations.

    • Tianshi Lu
    • Habib Hamidi
    • Barzin Y. Nabet
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-13

  • Single-particle tracking and mathematical modeling methods reveal the searching mechanism of CTCF for its cognate sites on DNA. An RNA-binding region in CTCF mediates its trapping in small zones and increases its target search efficiency.

    • Anders S. Hansen
    • Assaf Amitai
    • Xavier Darzacq
    Research
    Nature Chemical Biology
    Volume: 16, P: 257-266

  • Yellow rust fungus severely limits global wheat production and breeding of durable resistance is challenging. Here Klymiuk et al. isolate the broad-spectrum Yr15 resistance gene from wild emmer wheat and show that it is a member of a distinct tandem kinase-pseudokinase family of plant proteins.

    • Valentina Klymiuk
    • Elitsur Yaniv
    • Tzion Fahima
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12