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Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

Intramembranous and endochondral bone formation have been considered to be independent processes mediated by independent stem cells. Here the authors show that periosteal stem cells participate in both types of bone formation, supporting endochondral formation by producing Ihh.

Masayuki Tsukasaki
Noriko Komatsu
Hiroshi Takayanagi
ResearchOpen Access18 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance

PRMT arginine methyltransferases mediate post-translational modification. Takayanagi and colleagues show that a lack of PRMT5 in cells of the T cell lineage compromises their response to cytokines dependent on the common γ-chain, due to aberrant splicing of mRNA transcripts encoding the common γ-chain and its associated kinase JAK3.

Maia Inoue
Kazuo Okamoto
Hiroshi Takayanagi
Research15 Oct 2018
Nature Immunology

Volume: 19, P: 1265-1276
Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution

Osteoclasts are the body’s exclusive bone-resorbing cells; however, their differentiation trajectory remains unclear. Using single-cell RNA sequencing, Tsukasaki et al. provide a comprehensive road map of osteoclastogenesis, unveiling stepwise molecular events underlying osteoclast cell fate transitions.

Masayuki Tsukasaki
Nam Cong-Nhat Huynh
Hiroshi Takayanagi
Research07 Dec 2020
Nature Metabolism

Volume: 2, P: 1382-1390
Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A

Yusuke Arino
Asuka Terashima
Taku Saito
ResearchOpen Access25 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

Yuta Nakai
Kazuo Okamoto
Hiroshi Takayanagi
ResearchOpen Access03 Jan 2019
Bone Research

Volume: 7, P: 1-10

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Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance

Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution

Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A

Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

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