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The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation

The antibiotics kasugamycin, edeine and GE81112, inhibit translation initiation. Here, the authors present cryo-electron microscopy structures of 30S initiation intermediate complexes with these drugs revealing their mechanism of action.

Haaris A. Safdari
Martino Morici
Daniel N. Wilson
ResearchOpen Access12 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Structure of the 30S translation initiation complex

Angelita Simonetti
Stefano Marzi
Bruno P. Klaholz
Research31 Aug 2008
Nature

Volume: 455, P: 416-420
FAST, a method based on split-GFP for the detection in solution of proteins synthesized in cell-free expression systems

Thuy Duong Pham
Chiara Poletti
Anna Maria Giuliodori
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-16