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Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings

Immunocompromised individuals are predisposed to severe SARS-CoV-2 infection, with transplant recipients typically displaying impaired immune response to pathogens, due to typical life-long immunosuppressive treatment. In this work, the authors evaluate the immune response to Omicron subvariants BA.1 and BA.2 in organ transplant recipients across a diverse clinical spectrum.

Victor H. Ferreira
Javier T. Solera
Atul Humar
ResearchOpen Access04 Aug 2022
Nature Communications

Volume: 13, P: 1-12
Cytomegalovirus prophylaxis: how long is enough?

Extending the duration of cytomegalovirus prophylaxis to 6 months in virus-seronegative organ recipients who receive transplants from seropositive donors decreases the risk of cytomegalovirus disease. But is prophylaxis extension the best approach to preventing late-onset cytomegalovirus disease?

Deepali Kumar
Atul Humar
News & Views01 Jan 2010
Nature Reviews Nephrology

Volume: 6, P: 13-14
Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses

Delaying a second COVID-19 vaccine dose is a common strategy to maximize vaccine coverage, but the immunological effects are unclear. Hall et al. demonstrate that a delayed second dose significantly enhances neutralizing humoral immunity.

Victoria G. Hall
Victor H. Ferreira
Deepali Kumar
Research03 Feb 2022
Nature Immunology

Volume: 23, P: 380-385
Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion

Organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), are not offered for transplantation due to a high risk of transmission. Here, Galasso et al. develop a method for treatment of HCV-infected human donor lungs that is safe and prevents HCV transmission in the pig model.

Marcos Galasso
Jordan J. Feld
Marcelo Cypel
ResearchOpen Access29 Jan 2019
Nature Communications

Volume: 10, P: 1-12
Valganciclovir prophylaxis delays onset of EBV viremia in high-risk pediatric solid organ transplant recipients

Sawsan Albatati
Atul Sharma
Tom D. Blydt-Hansen
Research04 Aug 2019
Pediatric Research

Volume: 87, P: 892-896
T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients

Arnaud G. L’Huillier
Victor H. Ferreira
Deepali Kumar
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-9
High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation

Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national transplantation program.

Jenny N. Tran
Oliver P. Günther
Zoltán Kaló
ResearchOpen Access14 May 2021
Communications Biology

Volume: 4, P: 1-14

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Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings

Cytomegalovirus prophylaxis: how long is enough?

Delayed-interval BNT162b2 mRNA COVID-19 vaccination enhances humoral immunity and induces robust T cell responses

Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion

Valganciclovir prophylaxis delays onset of EBV viremia in high-risk pediatric solid organ transplant recipients

T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients

High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation

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