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Showing 1–3 of 3 results
Advanced filters: Author: Audre May Clear advanced filters

  • T cell activation is a process that requires extra nutrients, which could be difficult to source from the tumor microenvironment in competition with tumor cells. Here authors increase the metabolic fitness of CAR-T cells by stable overexpression of the glucose transporter GLUT1, which allows them to increase their glucose intake and enhances their antitumour function.

    • Justin A. Guerrero
    • Dorota D. Klysz
    • Crystal L. Mackall
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Combination of TCR or CAR T cells expressing the engineered CD47 variant 47E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.

    • Sean A. Yamada-Hunter
    • Johanna Theruvath
    • Crystal L. Mackall
    ResearchOpen Access
    Nature
    Volume: 630, P: 457-465