Fragile X Syndrome (FXS) patients and the mouse model of the disease are known to have increased neocortical network excitability and hypersensitivity to sensory stimuli. The current study describes dendritic ion channel dysfunction to underlie sensory hypersensitivity in the FXS mouse model, particularly due to the reduction and dysfunction of dendritic h- and BKCa channels. The study also shows pharmacological rescue of cortical hyperexcitability using BKCa channel openers.
- Yu Zhang
- Audrey Bonnan
- Andreas Frick
