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Showing 1–4 of 4 results
Advanced filters: Author: Augusto D Pichard Clear advanced filters

  • The ER exit site component Sec16A was identified as the target of Retro-2, a small-molecule inhibitor of protein toxins and pathogens. Retro-2 treatment alters retrograde early/maturing endosomes-to-Golgi trafficking of Shiga toxin.

    • Alison Forrester
    • Stefan J. Rathjen
    • Ludger Johannes
    Research
    Nature Chemical Biology
    Volume: 16, P: 327-336

  • Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • Alexander Teumer
    • Caroline S. Fox
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-19

  • Jonathan Marchini and colleagues with the Ox-GSK consortium report a meta-analysis for smoking phenotypes from 20 studies including 41,150 individuals, confirming an association at the CHRNA5–CHRNA3 locus on 15q25 to smoking quantity. They use imputation based on 1,000 Genomes Project Pilot 1 data to refine the association at this locus.

    • Jason Z Liu
    • Federica Tozzi
    • Jonathan Marchini
    Research
    Nature Genetics
    Volume: 42, P: 436-440