Mathematical modelling of the viral kinetics of hepatitis C infection can help inform clinicians of the optimal treatment regimens to achieve a sustained virologic response. In this Review, Perelson and Guedj describe the mathematical models and concepts used to understand hepatitis C infection, its response to antiviral treatment and whether HCV RNA is a reliable biomarker of viral kinetics.
- Alan S. Perelson
- Jeremie Guedj