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Showing 1–5 of 5 results
Advanced filters: Author: Avinash K. Shanmugam Clear advanced filters
  • Pecan is an important specialty crop that has experienced extensive interspecific hybridization and nearly-obligate outcrossing. Here, the authors assemble diploid genomes of four outbred genotypes, identify interspecific introgressions through comparative genomics analyses, and map QTLs associated with pest resistance.

    • John T. Lovell
    • Nolan B. Bentley
    • Jennifer J. Randall
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12
  • Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis.

    • Sreenath Nair
    • Anne M. Strohecker
    • Rajgopal Govindarajan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-20
  • Mutations in ENT3, encoded by SLC29A3, result in anaemia and erythroid hypoplasia, suggesting roles in erythropoiesis. Here the authors show that ENT3 acts as a lysosomal bile acid transporter, and mutation compromises taurine conjugated bile acid transport in erythroid progenitors leading to ER stress, and anaemia.

    • Avinash K. Persaud
    • Sreenath Nair
    • Rajgopal Govindarajan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18
  • Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

    • Meng How Tan
    • Qin Li
    • Jin Billy Li
    Research
    Nature
    Volume: 550, P: 249-254