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Showing 1–6 of 6 results
Advanced filters: Author: Avital A Rodal Clear advanced filters

  • Drosophila Skywalker regulates the GTPase Rab35, thereby controlling the turnover of synaptic-vesicle proteins. A new crystal structure of the TBC domain of Skywalker reveals an unexpected phosphoinositide-binding pocket, which is critical for synaptic function and is disrupted in DOORS syndrome–causing mutations in the human Skywalker homolog TBC1D24.

    • Steven J Del Signore
    • Avital A Rodal
    News & Views
    Nature Structural & Molecular Biology
    Volume: 23, P: 956-957

  • Mutations in tRNA ligases, essential components of the translational machinery, are associated with Charcot-Marie-Tooth peripheral neuropathy, but the mechanistic details are not known. The authors report that the tyrosyl-tRNA synthetase is an evolutionary-conserved F-actin organizer, and dysregulation of this function is associated with the disorder.

    • Biljana Ermanoska
    • Bob Asselbergh
    • Albena Jordanova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Quantitative points accumulation in nanoscale topography (qPAINT) makes use of predictable binding kinetics between DNA-PAINT imager and docking strands to achieve accurate and precise counting of molecules in spatially unresolved complexes.

    • Ralf Jungmann
    • Maier S Avendaño
    • Peng Yin
    Research
    Nature Methods
    Volume: 13, P: 439-442