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Showing 1–4 of 4 results

Advanced filters: Author: Avital Eisenberg-Lerner Clear advanced filters

Golgi organization is regulated by proteasomal degradation

Correct Golgi assembly is important to cellular homeostasis but regulation of its structure under stress remains unclear. Here, the authors identify stress-induced degradation of GM130 by Golgi-localized 26S proteasomes, leading to Golgi dispersal.

Avital Eisenberg-Lerner
Ron Benyair
Yifat Merbl
ResearchOpen Access21 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides

Cleavage products of the proteasome are profiled by mass spectrometry.

Hila Wolf-Levy
Aaron Javitt
Yifat Merbl
Research22 Oct 2018
Nature Biotechnology

Volume: 36, P: 1110-1116
The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC

Merbl and colleagues demonstrate that high expression of the proteasome regulator PSME4 is associated with immune-cold lung tumors and reduced antitumor immune responses, by functioning to modulate the protein degradome and antigen diversity.

Aaron Javitt
Merav D. Shmueli
Yifat Merbl
Research22 May 2023
Nature Cancer

Volume: 4, P: 629-647
Oxidative stress facilitates exogenous mitochondria internalization and survival in retinal ganglion precursor-like cells

Michal Aharoni-Simon
Keren Ben-Yaakov
Ziv Rotfogel
ResearchOpen Access24 Mar 2022
Scientific Reports

Volume: 12, P: 1-9