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Interferon action—sequence specificity of the ppp(A2′p)_nA-dependent ribonuclease

Daniel H. Wreschner
John W. McCauley
Ian M. Kerr
Research29 Jan 1981
Nature

Volume: 289, P: 414-417
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

Esha Madan
António M. Palma
Rajan Gogna
Research09 Dec 2024
Nature Biotechnology

P: 1-15
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

Single-cell RNA-sequencing analysis demonstrates that individual human brain organoids generate the cellular diversity of the cerebral cortex with organoid-to-organoid variability that is comparable to that of individual endogenous brains.

Silvia Velasco
Amanda J. Kedaigle
Paola Arlotta
Research05 Jun 2019
Nature

Volume: 570, P: 523-527
Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning

Combined high-throughput protein engineering with machine learning to curate libraries of CRISPR genome-editing enzymes with distinct genome targeting properties is described.

Rachel A. Silverstein
Nahye Kim
Benjamin P. Kleinstiver
Research22 Apr 2025
Nature

Volume: 643, P: 539-550
Brain Chimeroids reveal individual susceptibility to neurotoxic triggers

An analysis in 3D multidonor Chimeroids—a scalable multidonor human brain organoid model—shows that human genetic background may be an important mediator of neurotoxin susceptibility.

Noelia Antón-Bolaños
Irene Faravelli
Paola Arlotta
Research26 Jun 2024
Nature

Volume: 631, P: 142-149