Nature Search

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis

Therapy of tuberculosis is challenging, mainly due to complex structures of necrotic granulomas that often impair drug delivery. In this work, the authors show that the drug BTZ-043 fully penetrates necrotic granulomas and has potent lesional antibacterial activity.

Andreas Römpp
Axel Treu
Kerstin Walter
ResearchOpen Access18 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Observation of fractional spin textures in a Heusler material

Skyrmions and anti-skyrmions are magnetic textures that have garnered much interest due to their stability. Here, Jena et al demonstrate the existence of fractional spin textures at the edges of Heusler alloy sample, which can have continuous variable topological charges.

Jagannath Jena
Börge Göbel
Stuart S. P. Parkin
ResearchOpen Access29 Apr 2022
Nature Communications

Volume: 13, P: 1-8
NASH limits anti-tumour surveillance in immunotherapy-treated HCC

In hepatocellular carcinoma driven by non-alcoholic steatohepatitis, aberrant T cell activation and impaired immune surveillance seem to make hepatocellular carcinoma less responsive to anti-PD1 or anti-PDL1 immunotherapy.

Dominik Pfister
Nicolás Gonzalo Núñez
Mathias Heikenwalder
ResearchOpen Access24 Mar 2021
Nature

Volume: 592, P: 450-456
c-Maf-dependent T_reg cell control of intestinal T_H17 cells and IgA establishes host–microbiota homeostasis

An intricately linked homeostasis exists between the gut microbiome and host immune system. Scheffold and colleagues show that intestinal T_reg cells upregulate the transcription factor c-Maf in response to specific signals from the gut microenvironment to establish host–microbiota homeostasis.

Christian Neumann
Jonas Blume
Alexander Scheffold
Research18 Feb 2019
Nature Immunology

Volume: 20, P: 471-481
Distinct representations of olfactory information in different cortical centres

Dara L. Sosulski
Maria Lissitsyna Bloom
Sandeep Robert Datta
Research30 Mar 2011
Nature

Volume: 472, P: 213-216
The giant diploid faba genome unlocks variation in a global protein crop

Using a high-quality chromosome-scale assembly of the faba bean genome, the genetic basis of seed size and hilum colour is explored.

Murukarthick Jayakodi
Agnieszka A. Golicz
Stig Uggerhøj Andersen
ResearchOpen Access08 Mar 2023
Nature

Volume: 615, P: 652-659
Author Correction: c-Maf-dependent T_reg cell control of intestinal T_H17 cells and IgA establishes host–microbiota homeostasis

Christian Neumann
Jonas Blume
Alexander Scheffold
Amendments and Corrections23 May 2024
Nature Immunology

Volume: 25, P: 1306
Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

Progressive respiratory failure is the primary cause of death in patients with COVID-19, but pathologies in other tissues may also occur. Here the authors report that adrenal tropism of SARS-CoV-2 is associated with adrenalitis, reduced adrenal cortisol levels and severe adrenal damage in a post-mortem case series of patients with severe fatal COVID-19.

Tanja Paul
Stephan Ledderose
Martina Rudelius
ResearchOpen Access24 Mar 2022
Nature Communications

Volume: 13, P: 1-12
Holocentromeres can consist of merely a few megabase-sized satellite arrays

The centromere is required for the segregation of chromosomes. Here, the authors report the organization and dynamic of holocentric chromosomes, each containing 7 to 11 evenly spaced megabase-sized centromere-specific histone H3-positive units.

Yi-Tzu Kuo
Amanda Souza Câmara
Andreas Houben
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Unraveling the functional dark matter through global metagenomics

A computational approach to generate reference-free protein families from the sequence space in metagenomes reveals an enormously diverse functional space.

Georgios A. Pavlopoulos
Fotis A. Baltoumas
Nikos C. Kyrpides
ResearchOpen Access11 Oct 2023
Nature

Volume: 622, P: 594-602
Telomere maintenance by recombination in human cells

Melissa A. Dunham
Axel A. Neumann
Roger R. Reddel
Research01 Dec 2000
Nature Genetics

Volume: 26, P: 447-450
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.

Katy Börner
Philip D. Blood
Bruce W. Herr II
ResearchOpen Access13 Mar 2025
Nature Methods

Volume: 22, P: 845-860
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

Surgical adhesions are organ-joining bands of scar tissue that remain clinically untreatable. Here, the authors show that adhesions are formed through expansive mesothelial membrane bridges, and that blocking these with small molecules prevents formation of adhesions in mice.

Adrian Fischer
Tim Koopmans
Yuval Rinkevich
ResearchOpen Access17 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

Telomeric DNA is protected by the shelterin complex, whose disruption triggers DNA-damage responses, checkpoint activation and chromosomal fusions. Now analysis of human cell lines reveals a spontaneously occurring intermediate state in which the DNA-damage response is activated at the telomeres without cell cycle arrest or chromosomal fusions, and with TRF2 playing a central role in determining such a state.

Anthony J Cesare
Zeenia Kaul
Roger R Reddel
Research22 Nov 2009
Nature Structural & Molecular Biology

Volume: 16, P: 1244-1251
Characterization of pre-existing and induced SARS-CoV-2-specific CD8⁺ T cells

Functionally competent memory CD8⁺ T cells specific for different viral epitopes are induced by SARS-CoV-2 infection and can be detected in the absence of virus-specific antibodies.

Isabel Schulien
Janine Kemming
Christoph Neumann-Haefelin
Research12 Nov 2020
Nature Medicine

Volume: 27, P: 78-85
A genomic catalog of Earth’s microbiomes

Cataloging microbial genomes from Earth’s environments expands the known phylogenetic diversity of bacteria and archaea.

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
ResearchOpen Access09 Nov 2020
Nature Biotechnology

Volume: 39, P: 499-509
Defect dynamics in active smectics induced by confining geometry and topology

It is intriguing but challenging to control the complex dynamics of topological defects that emerge in nonequilibrium spatiotemporal systems. Through an effective modelling this work explores a viable way to controllably vary the properties of persistent defect dynamics in self-propelled active smectics via the competition of activity and boundary confinements with different topology and geometry.

Zhi-Feng Huang
Hartmut Löwen
Axel Voigt
ResearchOpen Access19 Nov 2022
Communications Physics

Volume: 5, P: 1-12
Ornithine capture by a translating ribosome controls bacterial polyamine synthesis

A combination of cellular, molecular and structural biology approaches explains how the translating ribosome and the nascent peptide SpeFL interact to form a binding pocket that serves as an ornithine sensor to regulate polyamine biosynthesis in pathogenic bacteria.

Alba Herrero del Valle
Britta Seip
C. Axel Innis
Research24 Feb 2020
Nature Microbiology

Volume: 5, P: 554-561
Telomere maintenance and cancer ? look, no telomerase

Axel A. Neumann
Roger R. Reddel
Reviews01 Nov 2002
Nature Reviews Cancer

Volume: 2, P: 879-884
Multicentric pilot study to standardize clinical whole exome sequencing (WES) for cancer patients

Michael Menzel
Stephan Ossowski
Albrecht Stenzinger
ResearchOpen Access20 Oct 2023
npj Precision Oncology

Volume: 7, P: 1-11
36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO

Michael J. Bloch
Ajay J. Kirtane
Patric Kröpil
ResearchOpen Access27 Sept 2024
Hypertension Research

Volume: 47, P: 3467-3472
Author Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access01 Apr 2021
Nature Biotechnology

Volume: 39, P: 521
Publisher Correction: A genomic catalog of Earth’s microbiomes

Stephen Nayfach
Simon Roux
Emiley A. Eloe-Fadrosh
Amendments and CorrectionsOpen Access18 Nov 2020
Nature Biotechnology

Volume: 39, P: 520
Genomic and transcriptomic comparison of post-radiation versus sporadic sarcomas

Tom Lesluyes
Jessica Baud
Frédéric Chibon
Research26 Jun 2019
Modern Pathology

Volume: 32, P: 1786-1794
Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene

Salvatore G. Caradonna
Nathan R. Einhorn
Jordan Marrocco
ResearchOpen Access16 Mar 2022
Translational Psychiatry

Volume: 12, P: 1-12
Faceting of Si and Ge crystals grown on deeply patterned Si substrates in the kinetic regime: phase-field modelling and experiments

Marco Albani
Roberto Bergamaschini
Francesco Montalenti
ResearchOpen Access22 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
Neuronal effects of glabellar botulinum toxin injections using a valenced inhibition task in borderline personality disorder

Tillmann H. C. Kruger
Jara Schulze
M. Axel Wollmer
ResearchOpen Access20 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
Tissue clearing to examine tumour complexity in three dimensions

This Review introduces the latest advances in tissue clearing and three-dimensional imaging as applied to epithelial tissues, and explains how such techniques can improve both our understanding of tumour biology and cancer diagnostics.

Jorge Almagro
Hendrik A. Messal
Axel Behrens
Reviews30 Jul 2021
Nature Reviews Cancer

Volume: 21, P: 718-730
Alterations in the p16^INK4a and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts

Jane R Noble
Ze-Huai Zhong
Roger R Reddel
Research26 Jan 2004
Oncogene

Volume: 23, P: 3116-3121
Association of polysialic acid serum levels with schizophrenia spectrum and bipolar disorder-related structural brain changes and hospitalization

Louisa Müller-Miny
Katharina Thiel
Jan D. Lünemann
ResearchOpen Access06 Feb 2023
Scientific Reports

Volume: 13, P: 1-10
Novel approach to push the limit of temporal resolution in ultrafast electron diffraction accelerators

Beñat Alberdi Esuain
Ji-Gwang Hwang
Thorsten Kamps
ResearchOpen Access03 Aug 2022
Scientific Reports

Volume: 12, P: 1-11
Tumour growth rate improves tumour assessment and first-line systemic treatment decision-making for immunotherapy in patients with liver metastatic uveal melanoma

Toulsie Ramtohul
Axel Cohen
Vincent Servois
Research26 Mar 2022
British Journal of Cancer

Volume: 127, P: 258-267
Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome

Ataaillah Benhaddou
Laetitia Gaston
Frédéric Chibon
ResearchOpen Access06 Dec 2021
Scientific Reports

Volume: 11, P: 1-17
Specific Electrogram Characteristics Identify the Extra-Pulmonary Vein Arrhythmogenic Sources of Persistent Atrial Fibrillation – Characterization of the Arrhythmogenic Electrogram Patterns During Atrial Fibrillation and Sinus Rhythm

Amir Jadidi
Mark Nothstein
Thomas Arentz
ResearchOpen Access04 Jun 2020
Scientific Reports

Volume: 10, P: 1-12
Multimodal analysis of formalin-fixed and paraffin-embedded tissue by MALDI imaging and fluorescence in situ hybridization for combined genetic and metabolic analysis

A new technical pipeline describes a combined approach of HER2/CEP17 fluorescence in situ hybridization (FISH) analysis with MALDI imaging on the very same section of formalin-fixed and paraffin-embedded (FFPE) tissue. Combining molecules detected by MALDI imaging with the gene copy number detected by HER2/CEP17 FISH, we found a synergistic effect which enhances patient prognosis.

Katharina Huber
Thomas Kunzke
Axel Walch
Research31 May 2019
Laboratory Investigation

Volume: 99, P: 1535-1546
Closing the gap between atomic-scale lattice deformations and continuum elasticity

Marco Salvalaglio
Axel Voigt
Ken R. Elder
ResearchOpen Access11 Apr 2019
npj Computational Materials

Volume: 5, P: 1-9
Exceptionally strong, stiff and hard hybrid material based on an elastomer and isotropically shaped ceramic nanoparticles

Prokopios Georgopanos
Gerold A. Schneider
Volker Abetz
ResearchOpen Access04 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit

Christian D Toouli
Lily I Huschtscha
Roger R Reddel
Research15 Jan 2002
Oncogene

Volume: 21, P: 128-139
Alternative lengthening of telomeres in mammalian cells

Jeremy D Henson
Axel A Neumann
Roger R Reddel
Reviews11 Feb 2002
Oncogene

Volume: 21, P: 598-610

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