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Showing 1–2 of 2 results
Advanced filters: Author: Axel Dietschmann Clear advanced filters

  • Candida albicans normally relies on specific pathogenicity mechanisms to cause tissue damage. This study reveals that when sensing host albumin, C. albicans, even avirulent strains, can trigger an alternative pathogenicity pathway via transcriptional and metabolic reprogramming.

    • Sophia U. J. Hitzler
    • Candela Fernández-Fernández
    • Mark S. Gresnigt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Gasdermin E pore formation has been associated with pyroptotic cell death. Here the authors identify gasdermin E pores in a subset of human TH17 cells and show that rather than killing these cells the pores enable the release of IL-1α on NLRP3 inflammasome activation as an antifungal immune response.

    • Ying-Yin Chao
    • Alisa Puhach
    • Christina E. Zielinski
    ResearchOpen Access
    Nature Immunology
    Volume: 24, P: 295-308