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Showing 1–2 of 2 results
Advanced filters: Author: Ayelet Rubenstein Clear advanced filters

  • Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab. Authors here show that the change in levels of the chemokine CXCL13 shortly following the start of siltuximab treatment is predictive of response.

    • Sheila K. Pierson
    • Laura Katz
    • David C. Fajgenbaum
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • By profiling immune cell variation in bone marrow of 54 genetically diverse mouse strains and analysing the evolutionary record, we found that genes associated with the frequency of a particular cell type but expressed in a different cell type increase the evolvability of the immune system.

    • Tania Dubovik
    • Martin Lukačišin
    • Shai S. Shen-Orr
    ResearchOpen Access
    Nature
    Volume: 632, P: 350-356