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Showing 1–3 of 3 results
Advanced filters: Author: Aygun Imanci Clear advanced filters
  • To improve our understanding of the pathological role of TET2 mutations, Pronier, Imanci et al. use mice and human cells to show that TET2 downregulation promotes the production of macrophage migration inhibitory factor (MIF). In addition they show that whilst TET2 is recruited to the MIF promoter in healthy monocytes, decreased TET2 expression results in chronic overproduction of MIF - suggesting that MIF signaling could therefore constitute a potential therapeutic target for conditions associated with TET2 mutations.

    • Elodie Pronier
    • Aygun Imanci
    • Nathalie M. Droin
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15
  • Receptor tyrosine kinases localize to the cell surface and have been suggested to also have nuclear function. Here the authors provide evidence that Colony Stimulating Factor-1 Receptor (CSF-1R) migrates to the nucleus upon CSF-1 stimulation in monocytes and that upon differentiation into macrophages, CSF-1R localizes to TSS, co-localizes with H3K4me3, and interacts with ELK and YY1.

    • Laura Bencheikh
    • M’Boyba Khadija Diop
    • Nathalie Droin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15
  • Chromatin and transcriptome studies in myelomonocytic leukemia stem cells revealed repression of retroelements and immune genes. Restoring these pathways by co-inhibiting DNA methylation and H3K9me2 enables selective targeting of leukemic cells.

    • Donia Hidaoui
    • Audrey Porquet
    • Françoise Porteu
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-18