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Showing 1–8 of 8 results

Advanced filters: Author: Ayijiang Yisimayi Clear advanced filters

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

A deep mutational scanning approach identifies mutations that allow subvariants of the prevalent JN.1 SARS-CoV-2 strain to evade Omicron-induced neutralizing antibodies, indicating a need for careful monitoring of this lineage in vaccine development.

Fanchong Jian
Jing Wang
Yunlong Cao
ResearchOpen Access07 Nov 2024
Nature

Volume: 637, P: 921-929
Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

Exposure to early variants of SARS-CoV-2 results in immune imprinting in mouse models and in humans, reducing neutralizing antibody titres against Omicron variants, which could be mitigated with multiple updated boosters.

Ayijiang Yisimayi
Weiliang Song
Yunlong Cao
ResearchOpen Access22 Nov 2023
Nature

Volume: 625, P: 148-156
Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

A high-throughput yeast display platform is used to analyse the profiles of mutations in the SARS-CoV-2 receptor-binding domain (RBD) that enable escape from antibodies, and suggests that most anti-RBD antibodies can be escaped by the Omicron variant.

Yunlong Cao
Jing Wang
Xiaoliang Sunney Xie
ResearchOpen Access23 Dec 2021
Nature

Volume: 602, P: 657-663
BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

Biochemical and structural studies of the interactions between antibodies and spike proteins from SARS-CoV-2 Omicron subvariants indicate how these variants have evolved to escape antibody-mediated neutralization.

Yunlong Cao
Ayijiang Yisimayi
Xiaoliang Sunney Xie
ResearchOpen Access17 Jun 2022
Nature

Volume: 608, P: 593-602
Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants

Broad and potent neutralizing antibodies to SARS-CoV-2 variants can be efficiently identified via accurate deep-mutational-scanning-based prediction of viral evolution and delivered to mice using mRNA–lipid nanoparticles.

Fanchong Jian
Anna Z. Wec
Yunlong Cao
ResearchOpen Access10 Jun 2025
Nature Microbiology

Volume: 10, P: 2003-2017
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Convergent mutations in hotspots of the SARS-CoV-2 Omicron receptor-binding domain can cause immune evasion and maintain sufficient ACE2-binding capability.

Yunlong Cao
Fanchong Jian
Xiaoliang Sunney Xie
ResearchOpen Access19 Dec 2022
Nature

Volume: 614, P: 521-529
Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines

Yunlong Cao
Ayijiang Yisimayi
Xiaoliang Sunney Xie
ResearchOpen Access21 May 2021
Cell Research

Volume: 31, P: 732-741
Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine

Yunlong Cao
Xiaohua Hao
Ronghua Jin
CorrespondenceOpen Access03 Dec 2021
Cell Research

Volume: 32, P: 107-109