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Showing 1–3 of 3 results
Advanced filters: Author: Aylwin C.Y. Ng Clear advanced filters

  • Caspase 8 is known to suppress necroptosis, but its relevant target protein was unknown. Ting and colleagues show that caspase 8 cleaves the deubiquitylase CYLD to inhibit necroptosis and promote cell survival.

    • Marie Anne O’Donnell
    • Eva Perez-Jimenez
    • Adrian T. Ting
    Research
    Nature Cell Biology
    Volume: 13, P: 1437-1442

  • Phagocytes employ multiple bactericidal mechanisms to kill microorganisms, including the generation of toxic superoxide and other reactive oxygen species. Here the authors utilize a multi-omics approach to identify and characterize new regulatory nodes implicated in mucosal immunity that control phagocyte oxidative burst.

    • Daniel B. Graham
    • Christine E. Becker
    • Ramnik J. Xavier
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • John Rioux and colleagues report results of a large genome-wide association meta-analysis and follow-up study of ulcerative colitis. They identify 29 new risk loci for this inflammatory disease and show that many risk loci are shared between ulcerative colitis and Crohn's disease.

    • Carl A Anderson
    • Gabrielle Boucher
    • John D Rioux
    Research
    Nature Genetics
    Volume: 43, P: 246-252