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Showing 1–3 of 3 results
Advanced filters: Author: Azad Farzadfard Clear advanced filters

  • Farzadfard et al. present a comprehensive analysis of a range of C-terminal truncations of aSN, linking the importance of high C-terminus charge for decreased fibrillation rates. The ability to formation oligomers, to disrupt synthetic vesicles and cell toxicity was reduced with truncated aSN, aiding in understanding of the intramolecular interactions of aSN which promote/inhibit aggregation.

    • Azad Farzadfard
    • Jannik Nedergaard Pedersen
    • Daniel Erik Otzen
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-10

  • The mechanism of α-synuclein amyloid aggregation via liquid–liquid phase separation has so far remained elusive. Now, the existence of nanoscale clusters of α-synuclein in sub-saturated concentrations is observed using mass photometry. These nanoscale clusters can act as precursors to both macroscopic condensate droplets as well as amyloid fibrils.

    • Soumik Ray
    • Thomas O. Mason
    • Alexander K. Buell
    Research
    Nature Chemistry
    Volume: 15, P: 1306-1316

  • Methods to quantitatively study liquid-liquid phase separation (LLPS) of proteins are lacking. Here the authors report Capillary flow experiments (Capflex) for the quantification of key LLPS parameters; they study Ddx4, the RP3 peptide and the aberrant liquid-to-solid phase transition of α-synuclein.

    • Emil G. P. Stender
    • Soumik Ray
    • Alexander K. Buell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18