Nature Search

LexA protein inhibits transcription of the E. coli uvrA gene in vitro

Aziz Sancar
Gwendolyn B. Sancar
David W. Mount
Research01 Jul 1982
Nature

Volume: 298, P: 96-98
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II

Ronny Drapkin
Joyce T. Reardon
Danny Reinberg
Research21 Apr 1994
Nature

Volume: 368, P: 769-772
Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock

Carol L Thompson
Aziz Sancar
Reviews16 Dec 2002
Oncogene

Volume: 21, P: 9043-9056
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

The clock protein Cry regulates hepatic glucose metabolism. Here the authors show that SREBP1c, activated by insulin signalling after feeding, directly regulates Cry transcription at specific circadian time points, and that Cry represses hepatic glucose production by promoting proteasomal degradation of Foxo1.

Hagoon Jang
Gha Young Lee
Jae Bum Kim
ResearchOpen Access14 Jul 2016
Nature Communications

Volume: 7, P: 1-14
The molecular origin of high DNA-repair efficiency by photolyase

Photolyase is an enzyme responsible for repairing DNA which is damaged after exposure to UV light. Here, the authors use site directed mutagenesis and femtosecond spectroscopy to study how photolyase achieves its maximal repair efficiency.

Chuang Tan
Zheyun Liu
Dongping Zhong
Research11 Jun 2015
Nature Communications

Volume: 6, P: 1-6
Precise mapping of single-stranded DNA breaks by sequence-templated erroneous DNA polymerase end-labelling

Identifying DNA lesions is key to assessing mutagenic activity. Here, the authors develop STEEL-seq, a method that maps single-stranded DNA breaks (SSBs) using a custom error-prone DNA polymerase. This approach reveals SSB enrichment near active promoters in the human genome.

Leonie Wenson
Johan Heldin
Ola Söderberg
ResearchOpen Access04 Aug 2025
Nature Communications

Volume: 16, P: 1-14
The intelligent clock and the Rube Goldberg clock

Circadian rhythms are generated by cell-autonomous molecular clocks in organisms ranging from cyanobacteria to humans. Recent research on the mechanisms of molecular clocks call for a reflection on the cause and necessity of complexity in biological systems.

Aziz Sancar
News & Views01 Jan 2008
Nature Structural & Molecular Biology

Volume: 15, P: 23-24
Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

Cisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across different mice organs following platinum treatment.

Askar Yimit
Ogun Adebali
Yuchao Jiang
ResearchOpen Access18 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Determination of plasmid molecular weights from ultraviolet sensitivities

AZIZ SANCAR
CLAUD S. RUPERT
Research01 Mar 1978
Nature

Volume: 272, P: 471-472
Genome-wide excision repair in Arabidopsis is coupled to transcription and reflects circadian gene expression patterns

Plants use nucleotide excision repair to maintain genome integrity in response to damage caused by stresses such as UV radiation. Here Oztas et al. use genome-wide profiling to show that excision repair in Arabidopsis is strongly coupled to transcription and reflects circadian patterns of gene expression.

Onur Oztas
Christopher P. Selby
Ogun Adebali
ResearchOpen Access17 Apr 2018
Nature Communications

Volume: 9, P: 1-8
Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase

The repair enzyme (6–4) photolyase uses light energy to cleave the ultraviolet-induced bond between pyrimidine dimers. These authors use ultrafast spectroscopy to examine the detailed electron and proton movements during the catalytic photocycle. Histidine 364 is identified as the crucial residue involved in the rate-limiting step.

Jiang Li
Zheyun Liu
Dongping Zhong
Research12 Aug 2010
Nature

Volume: 466, P: 887-890
Global repair is the primary nucleotide excision repair subpathway for the removal of pyrimidine-pyrimidone (6-4) damage from the Arabidopsis genome

Sezgi Kaya
Dugcar Ebrar Erdogan
Onur Oztas
ResearchOpen Access08 Feb 2024
Scientific Reports

Volume: 14, P: 1-9
Genome-wide mapping of nucleotide excision repair with XR-seq

Nucleotide excision repair is a conserved pathway to resolve bulky DNA adducts caused by different mutagens. XR-seq generates genome-wide repair maps of DNA damage across a range of organisms.

Jinchuan Hu
Wentao Li
Aziz Sancar
Protocols14 Dec 2018
Nature Protocols

Volume: 14, P: 248-282
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Siwei Chen
Bassel W. Abou-Khalil
Samuel F. Berkovic
Research03 Oct 2024
Nature Neuroscience

Volume: 27, P: 1864-1879
Hock immunization, a refined alternative for developing experimental autoimmune myasthenia gravis (EAMG) in mice

Marina Mané-Damas
Anja K. Schöttler
Pilar Martinez-Martinez
ResearchOpen Access29 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Genome-wide association meta-analyses identify 26 risk loci for epilepsy, including 19 loci specific to genetic generalized epilepsy. Prioritized candidate genes implicate synaptic processes and overlap with targets of antiseizure medications.

Remi Stevelink
Ciarán Campbell
Quratulain Zulfiqar Ali
ResearchOpen Access31 Aug 2023
Nature Genetics

Volume: 55, P: 1471-1482
Excision repair invades the territory of mismatch repair

Aziz Sancar
News & Views01 Mar 1999
Nature Genetics

Volume: 21, P: 247-249
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Here, the authors perform a meta-analysis in 26,699 people with seizures and 492,324 controls to identify 25 genome-wide significant copy-number variants. The discovered loci point to known disease genes and associations with clinical annotations.

Ludovica Montanucci
David Lewis-Smith
Dennis Lal
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Aryl hydrocarbon receptor interacting protein and syndromic gene variants detected in Turkish isolated pituitary adenoma families by whole exome sequencing

M. Eda Ertorer
Feyza N. Tuncer
Sema Yarman
ResearchOpen Access07 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Evaluation of anticancer effects of carboplatin–gelatin nanoparticles in different sizes synthesized with newly self-assembly method by exposure to IR light

Ferdane Danışman-Kalındemirtaş
İshak Afşin Kariper
Serap Erdem-Kuruca
ResearchOpen Access23 Jun 2022
Scientific Reports

Volume: 12, P: 1-11
The rare rs769301934 variant in NHLRC1 is a common cause of Lafora disease in Turkey

Garen Haryanyan
Ozkan Ozdemir
Nerses Bebek
Research11 Jun 2021
Journal of Human Genetics

Volume: 66, P: 1145-1151
Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability

Sibel Aylin Ugur Iseri
Emrah Yucesan
Ugur Ozbek
Research21 Feb 2019
Journal of Human Genetics

Volume: 64, P: 421-426
Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson’s disease patients

Zerrin Karaaslan
Özlem Timirci Kahraman
Cem İsmail Küçükali
ResearchOpen Access27 Jan 2021
Scientific Reports

Volume: 11, P: 1-16
Mechanistic Study of TTF-1 Modulation of Cellular Sensitivity to Cisplatin

Cody A. Phelps
Laura Lindsey-Boltz
David Mu
ResearchOpen Access29 May 2019
Scientific Reports

Volume: 9, P: 1-11
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Nynke A. Groenewold
Janna Marie Bas-Hoogendam
Nic J. A. Van der Wee
Research19 Jan 2023
Molecular Psychiatry

Volume: 28, P: 1079-1089
PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice

Clemens Messerschmidt
Marco Foddis
Celeste Sassi
ResearchOpen Access16 Mar 2021
Scientific Reports

Volume: 11, P: 1-11
A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms

Hilal Eren Gozel
Kıvanç Kök
Sadrettin Pence
ResearchOpen Access29 Sept 2021
Scientific Reports

Volume: 11, P: 1-12
Correction: The role of Extracellular Genomic Materials (EGMs) in psychiatric disorders

Ayşe Kurtulmuş
Cemal Çağıl Koçana
Selçuk Sözer
Amendments and CorrectionsOpen Access28 Aug 2023
Translational Psychiatry

Volume: 13, P: 1
The role of Extracellular Genomic Materials (EGMs) in psychiatric disorders

Ayşe Kurtulmuş
Cemal Çağıl Koçana
Selçuk Sözer
ReviewsOpen Access18 Jul 2023
Translational Psychiatry

Volume: 13, P: 1-17

Search

LexA protein inhibits transcription of the E. coli uvrA gene in vitro

Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II

Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

The molecular origin of high DNA-repair efficiency by photolyase

Precise mapping of single-stranded DNA breaks by sequence-templated erroneous DNA polymerase end-labelling

The intelligent clock and the Rube Goldberg clock

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

Determination of plasmid molecular weights from ultraviolet sensitivities

Genome-wide excision repair in Arabidopsis is coupled to transcription and reflects circadian gene expression patterns

Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase

Global repair is the primary nucleotide excision repair subpathway for the removal of pyrimidine-pyrimidone (6-4) damage from the Arabidopsis genome

Genome-wide mapping of nucleotide excision repair with XR-seq

Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

Hock immunization, a refined alternative for developing experimental autoimmune myasthenia gravis (EAMG) in mice

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Excision repair invades the territory of mismatch repair

Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Aryl hydrocarbon receptor interacting protein and syndromic gene variants detected in Turkish isolated pituitary adenoma families by whole exome sequencing

Evaluation of anticancer effects of carboplatin–gelatin nanoparticles in different sizes synthesized with newly self-assembly method by exposure to IR light

The rare rs769301934 variant in NHLRC1 is a common cause of Lafora disease in Turkey

Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability

Inflammation and regulatory T cell genes are differentially expressed in peripheral blood mononuclear cells of Parkinson’s disease patients

Mechanistic Study of TTF-1 Modulation of Cellular Sensitivity to Cisplatin

Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice

A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms

Correction: The role of Extracellular Genomic Materials (EGMs) in psychiatric disorders

The role of Extracellular Genomic Materials (EGMs) in psychiatric disorders

Search

Quick links

Search

Filter By:

Search

Quick links