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Showing 1–3 of 3 results
Advanced filters: Author: Aziza Elmesmari Clear advanced filters

  • MiR-155 is thought to inhibit PU.1 and thereby drive antigen-induced B-cell maturation. Here the authors show that patients with rheumatoid arthritis have high B-cell miR-155 expression and that an antagomir can rescue PU.1 expression, suggesting potential therapeutic avenues to treat rheumatoid arthritis.

    • Stefano Alivernini
    • Mariola Kurowska-Stolarska
    • Gianfranco Ferraccioli
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.

    • Mariola Kurowska-Stolarska
    • Stefano Alivernini
    • Iain B. McInnes
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13